the objective of this work was to develop bioadhesive topical gel of aceclofenac with the help of response-surface approach. experiments were performed according to a 3-level factorial design to evaluate the effects of two independent variables [amount of poloxamer 407 (pl-407 = x1) and hydroxypropylmethyl cellulose k100 m (hpmc = x2)] on the bioadhesive character of gel, rheological property o...

The present research work was focussed on the preparation as well as the evaluation of Aceclofenac solid dispersions for analgesic, anti-inflammatory and immunosuppressant activities. Solid dispersions were formulated using cros-carmellose sodium as polymer in different ratios. The solid dispersions were prepared using physical mixture, solvent evaporation and kneading techniques. The solid dis...

The aim of this study was to examine correlation between anti-inflammatory activity and molecular properties of the ten selected natural products in search of a lead compound through Molinspiration, Osiris and PASS cheminformatics software. Ten naturally occurring natural products of diverse chemical classes which seem to be promising and potential candidate for the drug development or identifi...

OBJECTIVES A prospective, multicenter, randomized, double-blind, placebo-controlled trial evaluated the effects of naftopidil 75 mg for medical expulsive therapy for a single ureter stone. MATERIALS AND METHODS Patients diagnosed with a ureter stone were prescribed aceclofenac 100 mg or a combined medication of tramadol 37.5 mg and acetaminophen 325 mg. Patients then randomly received either ...

The objective of the present investigation was to design suitable Immediate release tablet formulation of Aceclofenac by using cross carmellose sodium as super-disintegrant in four different concentrations i.e., 0, 4, 6, 8% w/w of tablet weight by two granulation methods i.e., Wet and melt granulation methods. The objective of the research was to compare the two granulation methods i.e., wet an...

Arthritis is a major cause of disability and morbidity, particularly in older individuals. The symptoms and signs of arthritis and related conditions include pain, stiffness, swelling, muscle weakness, and limitation of movement of the joints. The objective of the present work was to provide a dosage form for localized action of drugs used in treatment of arthritis to the affected tissues for p...