BID, a proapoptotic BCL-2 family member, plays an essential role in the tumor necrosis factor alpha (TNF-alpha)/Fas death receptor pathway in vivo. Activation of the TNF-R1 receptor results in the cleavage of BID into truncated BID (tBID), which translocates to the mitochondria and induces the activation of BAX or BAK. In TNF-alpha-activated FL5.12 cells, tBID becomes part of a 45-kDa cross-lin...

Archean Quartzose Rocks at Akilia, Greenland Fedo and Whitehouse (1) presented data to support their hypothesis that granulite grade quartz magnetite rocks on the island of Akilia, southwest Greenland—which are conformably interposed with pyroxenite and hornblendite units that date from before 3830 million years ago (Ma) (2–4)—had a metasomatic ultramafic igneous origin. They offered that inter...

Serpentinization is a widespread process that affects large-scale geodynamic processes along plate boundaries, including continental breakup, seafloor spreading, and subduction. Documenting the timing of serpentinization is critical for our understanding of these processes, but direct dating of serpentinites has been challenging or impossible. We present the first application of magnetite (U-Th...

Three distinct groups of eclogites (low-Mg–Ti eclogites, high-Ti eclogites and Mg-rich eclogites) and ultramafic rocks from the depth interval of 100–680 m of the Chinese Continental Scientific Drill Hole were studied. The lowMg#s (=100⁎molar Mg/(Mg+Fe)) (81–84%) and low Ni (1150–1220 ppm) and high Fe2O3 total (13–15 wt.%) contents of ultramafic rocks suggest a cumulate origin. Mgrich eclogites...

Archean Quartzose Rocks at Akilia, Greenland Fedo and Whitehouse (1) presented data to support their hypothesis that granulite grade quartz magnetite rocks on the island of Akilia, southwest Greenland—which are conformably interposed with pyroxenite and hornblendite units that date from before 3830 million years ago (Ma) (2–4)—had a metasomatic ultramafic igneous origin. They offered that inter...

Abstract Suprasubduction zone (SSZ) ophiolites of the northern Appalachians (eastern North America) have provided key constraints on fundamental tectonic processes responsible for evolution Appalachian orogen. The central and southern Appalachians, which extend from New York to Alabama (USA), also contain numerous ultramafic-mafic bodies that been interpreted as ophiolite fragments; however, th...

This article reports new geochemical, Sr-Nd-Hf-Pb and Re-Os data on the rocks of Middle Paleoproterozoic (1.99 Ga) Tiksheozero ultramafic-alkaline-carbonatite complex confined to northeastern margin Karelian Craton. We focus poorly studied silicate rocks. Based petrographic geochemical research, are subdivided into two groups: an ultramafic-mafic series depleted in REE, other incompatible eleme...