Objective: To construct and identify recombinant expression of a therapeutic tumor vaccine with HBcAg as a vector. Methods: PCR primers were designed according to the gene sequences of restriction enzyme sites of recombinant pKK233.2-hepatitis B core antigen (HBcAg) and melanoma-associated antigen 3 (MAGE-A3: 112120aa). The target fragment of MAGE-A3 was synthesized and cloned to pKK233.2-HBcAg...

Let A3 be the set of all positive integers pqr, where p, q, r are primes and possibly two, but not all three of them are equal. For any n = pqr ∈ A3, define a function w by w(n) = P (p + q)P (p + r)P (q + r), where P (m) is the largest prime factor of m. It is clear that if n = pqr ∈ A3, then w(n) ∈ A3. For any n ∈ A3, define w0(n) = n, wi(n) = w(wi−1(n)) for i = 1, 2, . . . . An element n ∈ A3...

i=1 Ai \⋃ k 6=i Ak  , {∑10 j=1 1Aj = 1} . (b) Setting A1 := B, A2 = A \ B and A3 = A, we see that Aj, j = 1, 2, 3, form a partition of Ω. The σ-algebra generated by the partition consists of all possible unions of its elements: σ({A,B}) = σ({A1, A3, A3}) = {∅, A1, A2, A3, A1 ∪ A2, A1 ∪ A3, A2 ∪ A3,Ω}. (c) No, F is not a σ-algebra, as the second axiom (A.2) fails: (B1 ×B2) doesn’t have the sp...

We decorated HS-functionalized cellulose nanocrystallite (CNC) films with monodisperse Au nanoparticles (AuNPs) to form a novel nanocomposite catalyst AuNPs@HS-CNC. The uniform, fine AuNPs were made by the reduction of HAuCl4 solution with thiol (HS-) group-functionalized CNC films. The AuNPs@HS-CNC nanocomposites were examined by X-ray photoelectron spectroscopy (XPS), TEM, ATR-IR and solid-st...

Escape swimming in the notaspid opisthobranch Pleurobranchaea is an episode of alternating dorsal and ventral body flexions that overrides all other behaviors. We have explored the structure of the central pattern generator (CPG) in the cerebropleural ganglion as part of a study of neural network interactions underlying decision making in normal behavior. The CPG comprises at least eight bilate...

Epithelial ovarian cancer (EOC) is the leading cause of death among gynecological malignancies and is rarely cured in the recurrent setting, mainly because of progressive chemoresistance, especially platinum resistance. In our previous studies, the platinum-resistance-related protein, annexin A3, was selected by comparative proteomics. In this study, we detected serum annexin A3 levels using a ...

Using elementary means, we derive an explicit formula for a3(n), the number of 3-core partitions of n, in terms of the prime factorization of 3n + 1. Based on this result, we are able to prove several infinite families of arithmetic results involving a3(n), one of which specializes to the recent result of Baruah and Berndt which states that, for all n ≥ 0, a3(4n + 1)= a3(n). 2000 Mathematics su...

The binding of peptides to MHC class I molecules induces MHC/peptide complexes that have specific conformational features. Little is known about the molecular and structural bases required for an optimal MHC/peptide association able to induce a dominant T cell response. We sought to characterize the interaction between purified HLA-A3 molecules and four well known CD8 epitopes from HIV-1 protei...

BACKGROUND We have investigated serum levels of immunoreactive marinobufagenin (MBG) in 16- to 20-week-old spontaneously hypertensive rats (SHRs)-A3 and in the normotensive Wistar-Kyoto (WKY) rat strain in the absence of salt loading, and we have investigated the genetic control of serum MBG. METHODS AND RESULTS We genotyped the F2 progeny of an SHR-A3×WKY intercross using a genome-wide panel...

The parasite Trypanosoma brucei, the causative agent of sleeping sickness across sub-Saharan Africa, depends on a remarkable U-insertion/deletion RNA editing process in its mitochondrion. A approximately 20 S multi-protein complex, called the editosome, is an essential machinery for editing pre-mRNA molecules encoding the majority of mitochondrial proteins. Editosomes contain a common core of t...