نتایج جستجو برای: 99mtc trodat 1
تعداد نتایج: 2756248 فیلتر نتایج به سال:
BACKGROUND AND PURPOSE We hypothesized that technetium-99m-ethylene dicysteine-metronidazole (99mTc-EC-MN) localizes to brain tissue that is hypoxic but viable. This study prospectively evaluated the relationship between neurological outcome and uptake of 99mTc-EC-MN in peri-infarcted regions of the brain. METHODS Eight patients with acute ischemic stroke in the territory of the left middle c...
in recent years, several radiopharmaceuticals have been developed for imaging regional cerebral blood flow (rcbf) such as 75se labelled pipse and mose, ²º¹ti labelled ddc and 99mtc labelled hmpao. hmpao with two asymmetric carbon atoms (at the 3 and 9 positions), produces d,1 and meso isomers, only one of which is retained in the brain. rapid intracellular conversion of 99mtc-d,1-hmpao to hydro...
The basic sensitivity of the Limulus test and the inhibitory factors were examined in 21 radiopharmaceuticals commonly used in Japan. The sensitivity of the Limulus test using pre-gel was found to be 1 mug/ml for Escherichia coli endotoxin. This sensitivity is about ten times that of the rabbit test adopted by USP and JP. The Limulus test was applicable, with full sensitivity and without inhibi...
OBJECTIVE To describe a protocol that was based on an integrative neurobiological model of scientific investigation to better understand the pathophysiology of obsessive-compulsive disorder and to present the clinical and demographic characteristics of the sample. METHOD A standardized research protocol that combines different methods of investigation (genetics, neuropsychology, morphometric ...
PURPOSE The aim of this study was to evaluate 99mTc-ethylenedicysteine-glucosamine (EC-DG) for the assessment of tumor growth. METHOD To evaluate whether 99mTc-EC-DG is involved in cell nuclei activity, in vitro thymidine incorporation, and cell-cycle assays of EC-DG were conducted using lung and breast cancer cells. Biodistribution of 99mTc-EC-DG in lung tumor-bearing mice (0.5-4 hours, 1 Ci...
This study aimed to prepare a novel radiopharmaceutical for the detection of brain disorders at early stages in susceptible patients.Promazine hydrochloride was labeled with 125I by direct electrophilic substitution reaction high labeling yields 92.6 ± 3.24 %. The yield and vitro stability 125I-promazine were determined paper electrophoresis, chromatography (PC) High performance liquid (HPLC). ...
In recent years, internet addiction disorder (IAD) has become more prevalent worldwide and the recognition of its devastating impact on the users and society has rapidly increased. However, the neurobiological mechanism of IAD has not bee fully expressed. The present study was designed to determine if the striatal dopamine transporter (DAT) levels measured by (99m)Tc-TRODAT-1 single photon emis...
Single photon emission computed tomography (SPECT) of dopamine transporters with Tc-TRODAT-1 has recently been proposed to provide valuable information of assessing the dopaminergic system. In order to measure the binding ratio of the nuclear medicine, registering magnetic resonance imaging (MRI) and SPECT image is a significant process. Therefore, an automated MRI/SPECT image registration algo...
BACKGROUND Due to aging and unexpected prolonged shutdown of nuclear reactors producing ⁹⁹Mo for ⁹⁹Mo/ 99mTc generators it was necessary to explore the alternative methods of technetium-99m production. The first choice were the accelerators. Three years ago IAEA (International Atomic Energy Agency) initiated the Coordinated Research Project "Accelerator-based Alternatives to Non-HEU production ...
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