Leea indica is a medicinal plant traditionally used to treat cancer. Through bioassay-guided approach, we isolated mollic acid arabinoside (MAA), for the first time from Leea indica. Here, we present the apoptosis-inducing effect of MAA on Ca Ski cervical cancer cells. Based on DAPI staining, MAA-treated cells manifested nuclear shrinkage, condensation, and fragmentation. We further confirmed t...

Previous studies with alcohol-associated malondialdehyde-acetaldehyde (MAA)-modified proteins have demonstrated an increase in the expression of adhesion molecules, and the secretion of pro-inflammatory cytokines/chemokines by rat sinusoidal liver endothelial cells (SECs). However, no studies have been initiated to examine the effects of MAA-modified proteins on the expression of the extracellu...

This randomized placebo-controlled cross-over trial assessed the effectiveness of a mandibular advancement appliance (MAA) in managing obstructive sleep apnoea (OSA). Twenty-one adults, with confirmed OSA, were provided with a maxillary placebo appliance and a MAA for 4-6 weeks each, in a randomized order. Questionnaires at baseline and after each appliance assessed bed-partners' reports of sno...

In a recent study we detected marked differences in the antigenic profile of acral lentiginous melanoma (ALM) and nodular melanoma lesions. Furthermore, we showed that the human high molecular weight melanoma-associated antigen (HMW-MAA) is expressed with a significantly higher frequency in metastatic than in primary ALM lesions. Because of the potential role of HMW-MAA in the metastatic proces...

The immunogenicity in patients with melanoma, in monkeys, and in rabbits of four human melanoma-associated antigens (MA A) defined by murine monoclonal antibodies was investigated. The latter included the high molecular weight MAA and the (M, 115,000,100,000, and 95,000150,000 MAA. To this end sera from patients with melanoma, from monkeys, and from rabbits immunized with cultured human melanom...

Considering the characteristics of Simulated Annealing Algorithm (SAA), based on the agents’ perception and retroaction to their surroundings, in this paper a new algorithm called Multi-agent Annealing Algorithm (MAA) is presented. And the global convergence of MAA is gotten. Finally, we make several numerical experiments to compare MAA with SAA and Genetic Algorithm (GA) by three classical tes...

Candida-associated denture stomatitis (CADS) is a significant clinical concern. We have demonstrated that urethane-based denture biomaterials with 10% methacrylic acid (MAA) could bind and then slowly release antifungal drug for months. Drugs on the resins could be repeatedly quenched/recharged, and in subsequent recharging, they could be changed/switched to more potent/effective ones. However,...

Malondialdehyde and acetaldehyde react together with proteins in a synergistic manner and form hybrid protein adducts, designated as MAA adducts. MAA-protein adducts are composed of two major products whose structures and mechanism of formation have been elucidated. MAA adduct formation, especially in the liver, has been demonstrated in vivo during ethanol consumption. These protein adducts are...