نتایج جستجو برای: 8 tetrahydro 1 benzothieno2
تعداد نتایج: 3083482 فیلتر نتایج به سال:
A quantitative structure-activity relationship (QSAR) study was conducted for the prediction of inhibitory activity of 1-phenyl[2H]-tetrahydro-triazine-3-one analogues as inhibitors of 5-Lipoxygenase. The inhibitory activities of the 1-phenyl[2H]-tetrahydro-triazine-3-one analogues modeled as a function of molecular structures using chemometrics methods such as multiple linear regression (MLR) ...
OBJECTIVES The present study was aimed to evaluate the anti-hyperlipidemic activity of newly synthesized tricyclic benzothieno 1, 2, 3-triazine derivatives namely CP-1 (3-(methyl)- 5,6,7,8-tetrahydro,3H-benzo[4,5] thieno [2,3-d][1,2,3] triazin-4-one), CP-2 (3-(ethyl)- 5,6,7,8-tetrahydro,3H-benzo[4,5] thieno [2,3-d][1,2,3] triazin-4-one) and CP-6 (3-(2-chloro phenyl)-5,6,7,8-tetrahydro,3H-benzo[...
The effects of 14 -carbolines on human platelet aggregability were comparatively studied, and the effects on lipid membranes were determined. Several -carbolines inhibited platelet aggregation induced by collagen, epinephrine, adenosine 5’-diphosphate, platelet-activating factor and thrombin. This activity was structure-dependent. Of all the compounds examined, 1-methyl-1,2,3,4tetrahydro-carbol...
Acrolein reacted with deoxyguanosine at pH 7 and 37 degrees to give three major products, Adducts 1 to 3, which were separated by high-performance liquid chromatography. They were identified by their ultraviolet, mass, and nuclear magnetic resonance spectra, by the spectra of the corresponding guanine derivatives, and by chemical transformations. Adducts 1 and 2 were two rapidly equilibrating d...
Two new sulfated triterpenoid saponins, zygophylosides Q (1) and R (2), have been isolated from the barks of Zygophyllum fabago L. Their structures were elucidated as 3beta,24,28,30-tetrahydro-urs-20-ene-24-O-sulphonyl-3-O-[beta-D-glucopyranosyl]-30-O-beta-D-glucopyranoside and 3beta,24,28,30-tetrahydro-urs-20-ene-24-O-sulphonyl-3-O-[beta-D-xylopyranosyl]-30-O-beta-D-glucopyranoside, respective...
Cyclization and chlorination of 2-amino-5-benzyl-4, 5, 6, 7-tetrahydro hydro thieno [3, 2c] pyridine-3carboxamide yielded (3 a-b). Reaction with different substituted pyridines of [3 a-b] yielded 4a (1-4) and 4b (1-2). However reaction of 3a with different substituted 2-amino phenols yielded 4a (5-6). Further 3a yields 4a (7) & 4a (8) from different substituents like o-phenylene diamine and 4-c...
retinoids with a tetrahydronaphthalene structure (Fig. 1), was synthesized using an NaHSO3 addition product of 5,6,7,8tetrahydro-5,5,8,8-tetramethyl-2-naphthalene-carboxaldehyde (compound I) as a starting material, which was prepared as described.1 The condensation of compound I and 4-ethylamino3-amino-ethylbenzoate (mp: 73 ̊C) in DMF for 70 h gave the title compound (recrystallized from hexane/...
Malaria persists as one of the most devastating global infectious diseases. The pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) has been identified as a new malaria drug target, and a triazolopyrimidine-based DHODH inhibitor 1 (DSM265) is in clinical development. We sought to identify compounds with higher potency against Plasmodium DHODH while showing greater selectivity to...
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