نتایج جستجو برای: 8 gdf8

تعداد نتایج: 655067  

2016
Ryan G. Walker Tommaso Poggioli Lida Katsimpardi Sean M. Buchanan Juhyun Oh Sam Wattrus Bettina Heidecker Yick W. Fong Lee L. Rubin Peter Ganz Thomas B. Thompson Amy J. Wagers Richard T. Lee

Circulation Research is available at http://circres.ahajournals.org DOI: 10.1161/CIRCRESAHA.116.308391 Abstract: Growth differentiation factor 11 (GDF11) and myostatin (or GDF8) are closely related members of the transforming growth factor β superfamily and are often perceived to serve similar or overlapping roles. Yet, despite commonalities in protein sequence, receptor utilization and signali...

2006
Lígia S.L.S. Mota Rogério A. Curi Darío A. Palmieri Alexandre S. Borges Catalina R. Lopes José D. Barbosa Marcos A. Gimenes

Within about 30 years the Brazilian buffalo (Bubalus bubalis) herd will reach approximately 50 million head as a result of the great adaptive capacity of these animals to tropical climates, together with the good productive and reproductive potential which make these animals an important animal protein source for poor and developing countries. The myostatin gene (GDF8) is important in the physi...

Journal: :Physiological genomics 2009
L Carraro S Ferraresso B Cardazzo C Romualdi C Montesissa F Gottardo T Patarnello M Castagnaro L Bargelloni

Dexamethasone (Dex), alone or in association with estrogens, is often illegally administered per os at very low dosage as a growth promoter in beef cattle, with effects that are opposite to the muscle wasting and atrophy induced by repeated administration at therapeutic dosages. In vitro and in vivo studies have investigated the catabolic effects of Dex at therapeutic doses on skeletal muscle, ...

Journal: :Science 2009

Journal: :نشریه شهرسازی و معماری 0

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2015
Amanda L. Kauffman Jason E. Ekert Alexandra V. Gyurdieva Michael A. Rycyzyn Pamela J. Hornby

Background: Relatively little has been reported comparing the ability of different induced pluripotent stem cells (iPSCs) and protocols to derive human intestinal organoids (HIO), although there is potential to supply HIO for translational research and regenerative medicine. In view of the time and effort required to differentiate HIO, protocols for differentiation were compared and five iPSC l...

2013
Ferenc Jeanplong Shelley J. Falconer Jenny M. Oldham Mark Thomas Tarra S. Gray Alex Hennebry Kenneth G. Matthews Frederick C. Kemp Ketan Patel Carole Berry Gina Nicholas Christopher D. McMahon

Myostatin plays a fundamental role in regulating the size of skeletal muscles. To date, only a single myostatin gene and no splice variants have been identified in mammals. Here we describe the splicing of a cryptic intron that removes the coding sequence for the receptor binding moiety of sheep myostatin. The deduced polypeptide sequence of the myostatin splice variant (MSV) contains a 256 ami...

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