an electroorganic reaction for the synthesis of 7-amino-2, 4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1h-pyrano[2, 3-d] pyrimidine-6-carbonitrile and ethyl-7-amino-2, 4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1h-pyrano[2, 3-d] pyrimidine-6-carboxylate derivatives are described, using an electrogenerated base of the anion of malonitrile or ethylcyanoacetate. this one-pot, three-component condensation of an a...

3-Arylhydrazono-2,4-dioxo-4-phenylbutanoateshave been prepared by the coupling of benzoylpyruvate with aryldiazonium chlorides.Reactions ofthe 3-arylhydrazono-2,4-dioxo-4-phenylbutanoateswith 1-aminoguanidine, semicarbazide, and thiosemicarbazidegave5-substituted 2-imino-6-azauracil (3a),6-azauracil (3b), and 2-thio-6-azauracil (3c), respectively. The analytical data of these compounds - IR, 1H...

The title complex, [Mg(C7H7N4O2)2(H2O)4], lies across an inversion centre and the Mg(II) atom is coordinated in a slightly distorted octa-hedral environment by four aqua ligands in the equatorial sites and two 1,3-dimethyl-2,6-dioxo-3,7-di-hydro-1H-purin-9-ide ligands, through imidazole ring N atoms, in the axial sites. An intra-molecular O-H⋯O hydrogen bond forms an S(7) graph-set motif. In th...

The title compound, C(31)H(38)O(10) [systematic name: (αR,4R,4aR,6aS,7R,8S,10R,11S)-methyl α,10-di-acet-oxy-4-(3-furyl)-4a,7,9,9-tetra-methyl-2,13-dioxo-1,4,4a,5,6,6a,7,8,9,10,11,12-dodeca-hydro-7,11-methano-2H-cyclo-octa-[f][2]benzo-pyran-8-acetate], was isolated from the seeds of Swietenia macrophylla. The mol-ecule contains four six-membered rings connected together in the shape of a bowl; o...

The biocatalyzed conversion of hyocholic acid (3α,6α,7α-trihydroxy-5β-cholan-24-oic acid) into ω-muricholic (3α,6α,7β-trihydroxy-5β-cholan-24-oic has been obtained exploiting a small library 7α- and 7β-HSDHs (hydroxysteroid dehydrogenases). process optimized performed avoiding the isolation 7-oxo intermediate using appropriate coupled enzymes for in situ cofactor regeneration. Moreover, reducti...

Starting from enantiomeric pure 1-[(3S,5R)- and 1-[(3R,5S)-3-(hydroxymethyl)-2-methylisoxazolidin-5-yl]-5-methylpyrimidine-2,4(1H,3H)-diones (-)7a and (+)7b, obtained by lipase-catalyzed resolution, pure diethyl{[(3S,5R)-2-methyl-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)isoxazolidin-3-yl]methyl}phosphonate (-)12a and diethyl{[(3R,5S)-2-methyl-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidi...

THE TITLE COMPOUND [SYSTEMATIC NAME: bis(2,5-dioxo-4,4-diphenylimidazolidin-1-ido-κN(1))bis(ethylenediamine-κ(2)N,N')cobalt(II)], [Co(C(15)H(11)N(2)O(2))(2)(C(2)H(8)N(2))(2)], has site symmetry . The Co(II) cation is located on an inversion center and coordinated by two phenytoin anions and two ethyl-enediamine ligands in a distorted octa-hedral geometry. In the phenytoin anion, the two phenyl ...

3-Arylhydrazono-2,4-dioxo-4-phenylbutanoates have been prepared by the coupling of benzoylpyruvate with aryldiazonium chlorides. Reactions of the 3-arylhydrazono-2,4- dioxo-4-phenylbutanoates with 1-aminoguanidine, semicarbazide, and thiosemicarbazide gave 5-substituted 2-imino-6-azauracil (3a), 6-azauracil (3b), and 2-thio-6-azauracil (3c), respectively. The analytical data of these compounds ...

Curcumol is one of the major components of the essential oil of Curcuma wenyujin with the structure of a guaiane-type sesquiterpenoid hemiketal. It exhibits clear antitumor, antihepatic fibrosis, antioxidant, and antimicrobial activities. In this article, the metabolism of curcumol in rats was investigated by characterizing metabolites excreted into urine. Sixteen phase 1 metabolites of curcumo...