UDP-glucuronosyltransferase (UGT)-mediated glucuronidation of benzo(a)pyrene-trans-7,8-dihydrodiol (BPD), precursor to the potent mutagen benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide, may be an important pathway in the detoxification of benzo(a)pyrene. To better characterize this pathway in humans, high-pressure liquid chromatography (HPLC) was used to detect glucuronide conjugates of BPD formed...

Community service activities are carried out in an effort to strengthen women's capacity so they can develop the jumputan batik home industry and millennial version of natural fashion designs. Operationally product community is cloth using dyes. The training materials for skills making patterns with characteristics, as well green campaigns on environmental preservation sustainable lifestyles th...

The title compound {systematic name: (1R,4S,4aS,7R,8aR)-4-bromo-7-[(1S,3R)-3-bromo-1,2,2-trimethyl-cyclo-pent-yl]-1,4a-dimethyl-deca-hydro-naphthalene-1,7,8a-triol}, C(20)H(34)Br(2)O(3), is a neoirieane-type bromo-diterpenoid isolated from Laurencia yonaguniensis Masuda et Abe, species inedita. The absolute stereochemistry was established as (1S,4R,5R,7R,10S,11S,14R). The structure displays int...

The methanolic extract of the whole plant of Echium glomeratum Poir. (Boraginaceae) has afforded five pyrrolizidine alkaloids, three that were (7S, 8R)-petranine (1), (7S, 8S)-petranine (2), and (7R, 8R)-petranine (3a) or (7R, 8S)-petranine (3b), comprising a tricyclic pyrrolizidine alkaloids subclass; and two that were known but to the species: 7-angeloylretronecine (4) and 9-angeloylretroneci...

AbsrrmrWe propose an estimation method of crosstalk noise for generic RC trees. The proposed method derives an analytic waveform of crosstalk noise in a 2-7r equivalent circuit. The peak voltage is calculated from the closed-form expression, and the crosstalk induced delay is estimated using the derived noise waveform. We also develop a transformation method from generic RC trees with branches ...

The syntheses of all stereoisomers of tetrasubstituted tetrahydrofuran lignan were accomplished, and the antimicrobial activity was examined. The 9,9'-diol compound bearing (7R,7'R,8R,8'R) and (7R,7'S,8R,8'R) stereochemistry showed the strongest antibacterial activity against Listeria denitrificans and Bacillus subtilis, respectively. It was also found that (-)-virgatusin bearing (7S,7'R,8S,8'S...

Interleukin (IL)-2 is a type I four-helical bundle cytokine that plays vital roles in antigen-mediated proliferation of peripheral blood T cells and also is critical for activation-induced cell death. We now demonstrate that IL-2 potently decreases expression of IL-7 receptor chain (IL-7R ) mRNA and protein. The fact that IL-7R is a component of the receptors for both IL-7 and thymic stromal ly...

We develop inequalities for the fraction of a bandlimited function's Lp norm which can be concentrated on any set of small 'Nyquist density'. We mention two applications. First, that a bandlimited function corrupted by impulsive noise can be reconstructed perfectly, provided the noise is concentrated on a set of Nyquist density < 1/7r. Second, that a wideband signal supported on a set of Nyquis...

The signals that maintain tissue-resident innate lymphoid cells (ILC) in different microenvironments are incompletely understood. Here we show that IL-7 receptor (IL-7R) is not strictly required for the development of any ILC subset, as residual cells persist in the small intestinal lamina propria (siLP) of adult and neonatal Il7ra-/- mice. Il7ra-/- ILC2 primarily express an ST2- phenotype, but...