BACKGROUND The physical health correlates of mild cognitive impairment (MCI) in the older individual are poorly known. The aim of this study was to investigate the relationship between physical health and MCI with population data. METHODS Subjects were 1,435 nondemented 75- to 95-year-old subjects. MCI was defined as scoring one standard deviation below age- and education-specific means on th...

INTRODUCTION We investigated the impact of reduced renal function on 24-h glucose variability in Japanese patients with type 2 diabetes mellitus (T2DM) treated with luseogliflozin. METHODS In this double-blind, placebo-controlled, crossover study, 37 Japanese patients with T2DM [glycated hemoglobin (HbA1c) 7.0-10.0%] and estimated glomerular filtration rate (eGFR) ≥45 mL/min/1.73 m(2) were ra...

BACKGROUND Although mild cognitive impairment is associated with an increased risk of developing dementia, there has been little work on its incidence and prevalence. AIMS To report age-specific prevalence, incidence and predictive validities for four diagnostic concepts of mild cognitive impairment. METHOD A community sample of 1045 dementia-free individuals aged 75 years and over was exam...

The year of 2005 marks the 75th anniversary since Trumpler (1930) provided the first definitive proof of interstellar grains by demonstrating the existence of general absorption and reddening of starlight in the galactic plane. This article reviews our progressive understanding of the nature of interstellar dust.

Synaptogenesis requires orchestrated intercellular communication between synaptic partners, with trans-synaptic signals necessarily traversing the extracellular synaptomatrix separating presynaptic and postsynaptic cells. Extracellular matrix metalloproteinases (Mmps) regulated by secreted tissue inhibitors of metalloproteinases (Timps), cleave secreted and membrane-associated targets to sculpt...

Migration of labor in response to structural changes in the U.S. economy is explored. An empirical study of the migration decision and wage determination is used to evaluate: 1) whether unemployment plays a larger role in motivating the decision to migrate than spatial wage differences and 2) whether the population can be characterized as homogeneous regarding migration and wage determination. ...

Most of the previous task functional magnetic resonance imaging (fMRI) studies found abnormalities in distributed brain regions in mild cognitive impairment (MCI) and Alzheimer's disease (AD), and few studies investigated the brain network dysfunction from the system level. In this meta-analysis, we aimed to examine brain network dysfunction in MCI and AD. We systematically searched task-based ...

Traumatic brain injury (TBI) is ranked as the fourth highest cause of death in the developed world. The majority of patients sustain mild TBI, and a significant number suffer persistent neuropsychological problems. Conventional neuroimaging methods (CT, MRI) do not reveal abnormalities consistent with the cognitive symptoms. Imaging methods offering prognostic information in acutely injured pat...

Abstract The effect of high pressure processing (300 and 600 MPa) combined with mild heat treatment (55 75 °C) on the colour parameters, anthocyanin content, sensory characteristics strawberry puree were examined after treatments 2 weeks cold storage at 15 °C. As an industrial scale simultaneous implementation these remains a challenge, HHP carried out consecutively in different sequences. para...

planned pregnancy among these countries is strikingly reflected in the disparity in abortion rates. The overall U. S. abortion rate (25.9 abortions per 1,000 women aged 15–44) is 1.7 times that of Canada (15.3 per 1,000) and more than four times that of the Netherlands (6.0 per 1,000).5 Differences in pregnancy rates, however, are not so marked. Again, the United States reports the highest rate...