نتایج جستجو برای: 6r robot

تعداد نتایج: 108295  

Journal: :The Journal of Experimental Medicine 1999
Simon A. Jones Daniela Novick Sankichi Horiuchi Naoki Yamamoto Alexander J. Szalai Gerald M. Fuller

The soluble interleukin 6 receptor (sIL-6R) circulates at elevated levels in various diseases. This suggests that inflammatory mediators control sIL-6R release. Through examination of human neutrophils, it was found that the acute phase reactant C-reactive protein (CRP) activates a threefold increase in sIL-6R production. Maximal release occurred after 30-60 min exposure to CRP (50 micrograms/m...

Journal: :The Journal of infectious diseases 1995
J T Frieling M van Deuren J Wijdenes J W van der Meer C Clement C J van der Linden R W Sauerwein

Concentrations of interleukin (IL)-6, soluble IL-6 receptor (sIL-6R), and soluble tumor necrosis factor receptor (sTNFR) p55 and p75 were measured in 25 patients with sepsis syndrome. Sequential blood samples were drawn from patients during a 7-h period. IL-6 concentrations were 34-763,000 pg/mL; they were higher in nonsurvivors than survivors, but the difference was not statistically significa...

Journal: :Revista Colombiana de Química 2022

El virus de la influenza A es el responsable gripe aviar, condición patológica que afecta principalmente aves, caballos y mamíferos marinos, sin embargo, subtipo H5N1 tiene capacidad infectar a los humanos forma rápida, exponiéndolos un posible evento pandémico. Por tanto, objetivo este estudio fue realizar acoplamiento molecular modelado tridimensional por homología flavonoides derivados ament...

Journal: :Clinical science 2012
Masahiko Mihara Misato Hashizume Hiroto Yoshida Miho Suzuki Masashi Shiina

IL (interleukin)-6, which was originally identified as a B-cell differentiation factor, is a multifunctional cytokine that regulates the immune response, haemopoiesis, the acute phase response and inflammation. IL-6 is produced by various types of cell and influences various cell types, and has multiple biological activities through its unique receptor system. IL-6 exerts its biological activit...

Journal: :American journal of physiology. Heart and circulatory physiology 2015
Steven W Copp Audrey J Stone Jianhua Li Marc P Kaufman

IL-6 signaling via the soluble IL-6 receptor (sIL-6r) has been shown to increase primary afferent responsiveness to noxious stimuli. This finding prompted us to test the hypothesis that IL-6 and sIL-6r would increase the exercise pressor reflex in decerebrate rats with freely perfused femoral arteries. We also tested the hypothesis that soluble glycoprotein (sgp)130, an inhibitor of IL-6/sIL-6r...

Journal: :Molecular cancer therapeutics 2006
Tin Lap Lee Jason Yeh Carter Van Waes Zhong Chen

Signal transducer and activator of transcription 3 (STAT3) has been reported to be activated by interleukin-6 receptor (IL-6R) or epidermal growth factor receptor (EGFR) in head and neck squamous cell carcinomas (HNSCC), which may have important implications for responsiveness to therapeutics targeted at EGFR, IL-6R, or intermediary kinases. Suppressor of cytokine signaling-1 (SOCS-1) has been ...

2015
Cunjie Li Ting Lei

BACKGROUND Diabetic nephropathy (DN) is one of the most significant long-term complications of diabetes mellitus (DM), and it is a primary risk factor for end-stage renal disease. MicroRNAs (miRNAs) play important roles in regulating the expression of genes, including interleukin-6R (IL-6R), which has been reported to be involved in the development of DNDN. The aim of this study was to identify...

2013
Ricardo C. Ferreira Daniel F. Freitag Antony J. Cutler Joanna M. M. Howson Daniel B. Rainbow Deborah J. Smyth Stephen Kaptoge Pamela Clarke Charlotte Boreham Richard M. Coulson Marcin L. Pekalski Wei-Min Chen Suna Onengut-Gumuscu Stephen S. Rich Adam S. Butterworth Anders Malarstig John Danesh John A. Todd

Inflammation, which is directly regulated by interleukin-6 (IL-6) signaling, is implicated in the etiology of several chronic diseases. Although a common, non-synonymous variant in the IL-6 receptor gene (IL6R Asp358Ala; rs2228145 A>C) is associated with the risk of several common diseases, with the 358Ala allele conferring protection from coronary heart disease (CHD), rheumatoid arthritis (RA)...

2016
Hui Chen Xiongze Zhang Nanying Liao Feng Wen

PURPOSE Trans-signaling of interleukin (IL)-6 through its soluble receptor (sIL-6R) is critically involved in the promotion of chronic inflammatory diseases. The aim of the present study was to estimate IL-6, sIL-6R, and soluble gp130 (sgp130, a natural antagonist of IL-6 trans-signaling) concentrations in the serum and aqueous humor (AqH) of patients with diabetic retinopathy (DR). METHODS P...

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