Abstract BACKGROUND Newly diagnosed glioblastoma (nGBM) has dismal outcomes with survival of 15-18 months. Tumor associated “survivin” is expressed in > 95% nGBM and targetable by SurVaxM immunotherapy. METHODS patients (pts) were enrolled this Phase 2 study, age ≥ 18, KPS 70, IHC confirmed surviving-expression, expression HLA-A*02, A*03, A*11 or A*24 MHC-I alleles residual contrast enha...

Background. The burden of pneumococcal disease in patients (pts) with end stage renal disease (ESRD) is high, with S. pneumoniae accounting for more than half of the reported cases of pneumonia in dialysis pts. A diminished immune response to pneumococcal polysaccharide vaccine can be observed in pts with chronic renal failure requiring dialysis. The response to 13-valent conjugate pneumococcal...

Methods In prospective study were included 45 pts(19b/26g) with sJIA refractory to conventional treatment, who was treated by TCZ from 9 months to 54 months. At baseline mean age of 6.25(2.0-17.8)yrs; mean disease duration of 4.5(0.315.9)yrs. TCZ used as the 1 B in 28 pts, 2 – in 12, 3 – in 5. 37.8% pts previously received B:TNF-ingibitors-17, abatacept–2, rituximab–3. 41 pts(91.1%) had arthrit...

This longitudinal study of 27 infants examined the development of pulling-to-stand (PTS). In general, infants began PTS using a two-leg strategy and transitioned to a half-kneel strategy. As a group, infants showed no preference for either strategy at the onset of PTS, switching between strategies until half-kneeling became the dominant pattern about 1 month after the onset of PTS. Examination ...

OBJECTIVE To investigate whether adolescent siblings of childhood cancer survivors experience posttraumatic stress (PTS). METHODS Participants included 78 adolescent siblings of adolescent cancer survivors who completed self-report measures of anxiety, PTS, and perceptions of the cancer experience. RESULTS Nearly half (49%) of our sample reported mild PTS and 32% indicated moderate to sever...

Background MRI has generally been contraindicated in patients (pts) with pacemakers (PM) or defibrillators (ICD) due to concern of a variety of potential complications. Several recent series have suggested potential safety of MRI in pts with cardiac devices, but most excluded cardiac or thoracic imaging. Additionally there is very limited data on safety of CMR in pts with devices, especially in...

Methods: 33 pts with progressive well differentiated NETs (G1,G2) were treated with everolimus 10 mg q.d. combined with octreotide LAR 30-40 mg till progression or intolerable toxicity. All pts were evaluable for efficacy and toxicity. The mean age was 54 years (25-72), 11 male, 22 female. The most of pts had pancreatic NETs–13 (39%) pts. There were 19 (57,6%) NETs of foregut origin, 8 (24,2%) ...

Methods We retrospectively investigated 146 patients (131 men, 16 women; mean age, 67 years) with severe functional mitral valve (MV) insufficiency due to dilated cardiomyopathy that were operated on between 2004 till 2012. 35 pts were in New York Heart Association class IV and 102 were in class III. Most of pts had severe enlarged LV (mean end-diastolic size 73.7±7,1ml and volume 293 ±80ml) wi...

The phosphoenolpyruvate(PEP):carbohydrate phosphotransferase system (PTS) is found only in bacteria, where it catalyzes the transport and phosphorylation of numerous monosaccharides, disaccharides, amino sugars, polyols, and other sugar derivatives. To carry out its catalytic function in sugar transport and phosphorylation, the PTS uses PEP as an energy source and phosphoryl donor. The phosphor...

[Purpose] This study explored the roles of physical therapists (PTs) in introducing assistive products, which are essential for living securely and stably at home, and examined how PTs can fulfill these roles more efficiently and effectively. [Subjects and Methods] A questionnaire on introducing assistive products was administered to PTs working at randomly selected hospitals, health-care facil...