The use of computer-based tools and methods in the development process is essential respectively quality, time and costs. Meanwhile the general business conditions are similar worldwide: product life cycles decline drastically and technological leadership of the highest possible quality is required in order to react to constantly increasing innovation dynamics. Engineers have to decrease the ti...

K. G. Leach,1,* P. E. Garrett,1,2 C. E. Svensson,1 I. S. Towner,3 G. C. Ball,4 V. Bildstein,1 B. A. Brown,5,6 A. Diaz Varela,1 R. Dunlop,1 T. Faestermann,7 R. Hertenberger,8 D. J. Jamieson,1 R. Krücken,4,7 S. Triambak,1,† and H.-F. Wirth8 1Department of Physics, University of Guelph, Guelph, Ontario N1G 2W1, Canada 2Excellence Cluster Universe, Boltzmannstraße 2, D-85748 Garching, Germany 3Cycl...

Experimental results from volumetric 3-D vector flow measurements using a 62+62 row-column addressed (RCA) array are presented. A plane-by-plane steered transmit sequence and its post processing steps are described for obtaining 3-D vector flow in a volume. A modified version of the transverse oscillation (TO) velocity estimator is used, which exploits the focal lines generated with the tall el...

In our search for new anticancer therapies, some compounds synthesized in our lab were selected and their potential cytotoxic activity was evaluated in vitro against two cancer cells lines including a solid tumor (UACC-62, melanoma) and a human lymphoma (JURKAT). Compounds showing cytotoxic activity were subjected to an apoptosis assay. Two compounds showed promising results.

KY-62 is a water-soluble analog of amphotericin B. In vitro testing of five clinical isolates of Candida albicans showed KY-62 to have potency similar to that of amphotericin B. KY-62 was administered to mice infected intravenously with C. albicans. In vivo, KY-62 was effective in immunocompetent mice, with potency similar to that of amphotericin B. KY-62 was well tolerated up to 30 mg/kg of bo...