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We assessed the efficacy of simultaneous agonism at the glucagon-like peptide-1 receptor (GLP-1R) and the melanocortin-4 receptor (MC4R) for the treatment of obesity and diabetes in rodents. Diet-induced obese (DIO) mice were chronically treated with either the long-acting GLP-1R agonist liraglutide, the MC4R agonist RM-493 or a combination of RM-493 and liraglutide. Co-treatment of DIO mice wi...
Coccidioidomycosis is endemic to the southwestern United States; 60% of nationally reported cases occur in Arizona. Although the Council of State and Territorial Epidemiologists case definition for coccidioidomycosis requires laboratory and clinical criteria, Arizona uses only laboratory criteria. To validate this case definition and characterize the effects of coccidioidomycosis in Arizona, we...
Cancer therapies based on nanoparticles with a loaded drug can overcome the problem of drug’s toxic effects in traditional chemotherapeutic approach. In this study, we LLY-507, potent inhibitor SMYD2, methyltransferase enzyme, iron oxide (IONPs). The prepared were characterized by microscopic analysis, loading efficiency, and release studies. Microscopic examination revealed an average grain si...
BACKGROUND Older persons who re hospitalized for acute illnesses often lose their independence and are discharged to institutions for long-term care. METHODS We studied 651 patients 70 years of age or older who were admitted for general medical care at a teaching hospital; these patients were randomly assigned to receive usual care or to be cared for in a special unit designed to help older p...
Establishment of switchgrass (Panicum virgatum L.) is challenging, and failure in establishment may expose growers to considerable economic risk. The objectives this research were (i) evaluate whether management practices are variety-specific for the (ii) assess effectiveness cover crops as preceding on ‘Shawnee’ establishment. Therefore, two studies conducted at University Massachusetts Agricu...
The aim of this study was to investigate the frequency, location and type of rpoB gene mutations in Mycobacterium tuberculosis (MTB) collected from patients in the southern endemic region of Iran. Drug susceptibility testing was determined by using the BACTEC system and the center for diseases control’s (CDC) standard conventional proportional method. In 29 rifampicin-resistant MTB (85%) isolat...
1 Research Structural Engineer, Director of Aerodynamics Laboratory (HRDI-07), Federal Highway Administration, 6300 Georgetown Pike, McLean, Virginia 22101; PH (202) 493-3031; FAX (202) 493-3442; email: [email protected] 2 Hydraulic Research Engineer, GKY and Associates, Inc., 5411-E Backlick Road, Springfield, Virginia 22151; PH (703) 642-5080; FAX (703) 642-5367; email: kornel.kerenyi...
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