The inducible isoforms of nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) are overexpressed in colonic tumors of humans, as well as in colon tumors that develop in rats after the administration of the colon-specific carcinogen, azoxymethane (AOM). iNOS may regulate COX-2 production of proinflammatory prostaglandins, which are known to play a key role in colon tumor development. Experime...

Carbon monoxide (CO) confers anti-inflammatory protection in rodent models of lung injury when applied at low concentration. Translation of these findings to clinical therapies for pulmonary inflammation requires validation in higher mammals. We have evaluated the efficacy of inhaled CO in reducing LPS-induced lung inflammation in cynomolgus macaques. LPS inhalation resulted in profound neutrop...

A series of five experiments was conducted to evaluate and investigate mode of transfer of an amino acid chelated iron fed to the sow as a hematinic for the baby pig. In the first experiment, >3,000 ppm iron (Fe) were provided to 1A the sows daily as the amino acid chelate (FeP) from late gestation through 3 weeks of lactation. Mean hemoglobin (Hb) among pigs of FeP-fed sows was 8.5g/dl by 2 we...

Overview of Issue In the past two years research has pointed towards the possibility of using urban planning as a tool to reduce greenhouse gas emissions in urban areas. For many focused on the issue of climate change, there is a consensus that atmospheric carbon dioxide should be contained at no more than twice the maximum level of atmospheric carbon dioxide that existed during the pre-industr...

oeliac disease (CD) is the only common disease for which strict dietary compliance is the sole treatment. Sensitivity to Cgluten varies between patients with CD, so that restricting levels in food tounder onepart permillion (ppm)wouldprotect the maximum number of patients. In a daily diet of 500 g food, 1 ppm is equivalent to 0.5 mg, the amount in 1/5000 of a slice of wheat flour bread containi...

This paper reports the inhibition efficiency of a family of polyaminoamide (PAMAM) STARBURST® dendrimers in colloidal SiO2 growth. PAMAMs of various generations (0.5, 1.5, 2.5 with –COOH termini, and 1, and 2 with –NH2 termini) were tested and compared to control samples. Superiority of the dendrimer inhibitors with –NH2 termini (maintaining∼380 ppm soluble SiO2 after 12 h) versus those with –C...

Oxyphytosterols (OPS) were fed to hamsters, at different concentrations, in order to observe their eventual incorporation into plasma, aorta, liver, kidneys and heart. The animals receiving the very high level (2500 ppm) presented 7beta-hydroxycampesterol, beta-epoxycampesterol, campestanetriol, 7-ketocampesterol, 7beta-hydroxysitosterol, beta-epoxysitosterol, sitostanetriol and 7-ketositostero...

The influence of a permitted yellow food colour, Sunset yellow –FCF on root tips of Allium sativum was investigated with a view to ascertaining its mitodepressive effect. Root tips of Allium sativum were treated with five concentrations of Sunset yellow like 100 ppm,250 ppm,500 ppm,750 ppm and 1000 ppm and with distilled water as control. The time of action of the respective concentration of so...

AIM This was to compare the salivary fluoride levels following tooth brushing with amine fluoride toothpastes containing three different concentrations of F (250 ppm F, 500 ppm F and 1250 ppm F) and to evaluate the effect of rinsing with water on the oral fluoride levels up to 90 min. METHODS A double blind randomised six-arm crossover study was conducted with 32 child participants. Patients ...