نتایج جستجو برای: 5 fluorouracil colon cancer

تعداد نتایج: 2083830  

2016
Senlin Zhao Huamei Tang Dongwang Yan Junwei Fan Hongcheng Sun Yugang Wen Fudong Yu Feifei Cui Dongyuan Zhang Yingming Xue Chenchen Liu Ben Yue Jian Chen Jingtao Wang Xiao Wang Meng Zhang Yang Yu Weiliang Jiang Xisheng Liu Yushuai Mi Zongguang Zhou Xuebin Qin Zhihai Peng

Conventional high-recurrence risk factors are not sufficient to predict post-operative risk of tumor recurrence or sensitivity to 5-fluorouracil (5-FU)-based chemotherapy for stage II colon cancer. DDA1, an evolutionarily conserved gene located at 19p13.11, may be involved in the activation of nuclear factor kappaB (NFκB). This study aimed to investigate whether DDA1 contributes to tumorigenesi...

Journal: :The British journal of ophthalmology 2005
Q D Nguyen S Shah S Tatlipinar D V Do E V Anden P A Campochiaro

Bevacizumab (Avastin, Genentech) is a recombinant humanised, full length, antiVEGF monoclonal antibody that binds all isoforms of VEGF-A. It has been shown to prolong survival of patients with advanced colon cancer when combined with 5-fluorouracil. In this report, we describe the effect of bevacizumab in two patients with choroidal neovascularisation (CNV) secondary to pathological myopia, whi...

2015
Huanan Wang Lingling Zhang Xu Yang Yipeng Jin Shimin Pei Di Zhang Hong Zhang Bin Zhou Yingjie Zhang Degui Lin

Colon cancer is the third most common cancer in humans which has a high mortality rate, and 5-Fluorouracil (5-FU) is one of the most widely used drugs in colon cancer therapy. However, acquired chemoresistance is becoming the major challenges for patients, and the molecular mechanism underlying the development of 5-FU resistance is still poorly understood. In this study, a newly designed therap...

Journal: :Journal of pharmaceutical sciences 2001
J S Lee Y J Jung Y M Kim

N-nicotinyl-2-(5-fluorouracil-1-yl)-D,L-glycine (NFG) and N-isonicotinyl-2-(5-fluorouracil-1-yl)-D,L-glycine (INFG) were synthesized as colon-specific prodrugs of 5-fluorouracil (5-FU). As N-aromatic acyl amides of glycine, they are expected to be stable in the upper intestine and delivered to the colon as an intact form if they are nonabsorbable. Microbial hydrolysis of amide bond in the colon...

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