In the present investigation, a series of novel isoxazoline derivatives 4a-i were synthesized by cyclization of 1-(2’-hydroxy phenyl)-5-(6’’-methoxynaphthalen)-2-propene-1-one (i.e. Chalcones) 3a-i with hydroxylamine hydrochloride in dimethyl formamide and sodium acetate to obtained 3-(2’-hydroxy phenyl)-5-(6’’-methoxynaphthalen)-2-isoxazolines 4a-i. The structures of newly synthesized compound...

The acetylation modification process of histone has an essential role in the epigenetic regulation gene expression. This is controlled by balance between deacetylases (HDAC) and acetyltransferases (HAT). HDACs are thought to be vital for cell function. Particularly, higher HDAC expression frequent various cancers, resulting dysregulation several target genes involved proliferation, differentiat...

The synthesis and physicochemical properties of a range of 2- and 6-amido-3-hydroxypyridin-4-ones are described. All the amido-substituted 3-hydroxypyridin-4-ones have lower pK(a) values than 1,2-dimethyl-3-hydroxypyridin-4-one (deferiprone). This is due to the inductive effect of the amido group. Furthermore, the pK(a) values of the 3-hydroxy group in 1-nonsubstituted pyridinones are dramatica...

This study examines the pyrolysis products of smoked methamphetamine mixed with tobacco that was trapped with a C8 adsorbent cartridge and then detected by gas chromatography-tandem mass spectrometry. According to the results, the mainstream smoke contains 2-methylpropyl-benzene, 2-chloropropyl-benzene, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one, 3-ethyl-phenol, methamphetamine, dimethyl...

The formal [3 + 2]-photocycloaddition of 2-hydroxy- (2a) and 2-amino-1,4-naphthoquinone (2b) to olefins was studied in various solvents aiming at a possible enantioselective reaction course. The reaction conditions were optimised for irradiation at low temperature in a nonpolar solvent employing external fluorescent lamps as irradiation sources. Best yields for the reaction of 2-hydroxy-1,4-nap...