Human cytochrome P450 3A4 (CYP3A4) is responsible for the metabolism of more than half of pharmaceutic drugs, and inactivation of CYP3A4 can lead to adverse drug-drug interactions. The substituted imidazole compounds 5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine (SCH 66712) and 1-[(2-ethyl-4-methyl-1H-imidazol-5-yl)methyl]-4-[4-(trifluoromethyl)-2-pyridinyl]piperazi...

In continuation of our research program to develop original synthetic methods using TDAE methodology on nitroheterocyclic substrates, we were able generate for the first time a stable carbanion in position 2 5-nitroimidazole scaffold. Starting from 2-chloromethyl-4-phenylsulfonylmethyl-5-nitroimidazole intermediate, prepared by vicarious nucleophilic substitution hydrogen (VNS) reaction, select...

In the title compound, C(10)H(8)N(6)·2H(2)O, the central aromatic ring makes dihedral angles of 23.59 (15) and 16.99 (16)° with the terminal imidazole and tetra-zole rings, respectively, which are themselves almost coplanar [dihedral angle = 6.61 (18)°]. Two H atoms of the two water mol-ecules are half occupied. In the crystal packing, weak inter-molecular O-H⋯N, O-H⋯O and N-H⋯N hydrogen bonds ...

The title compound, C(20)H(20)N(6), was isolated from dimethyl sulfoxide solution using 2-(1H-imidazol-2-yl)pyridine and 1,4-dichloro-butane in the presence of NaOH.

In the title compound, [Cd(C(10)H(7)N(6))(2)(H(2)O)(2)], the Cd(II) atom lies on an inversion centre and is coordinated by four N atoms from 5-[4-(1H-imidazol-1-yl)phen-yl]tetra-zol-1-ide ligands and two O atoms from the coordinated water mol-ecules in an octa-hedral arrangement. The complex polymeric chains are inter-connected via inter-molecular water O-H⋯N hydrogen bonds into a three-dimensi...