I. The Pharmacology of No. 48-80, a Long-Acting Vasodepressor Drug. Peter B. Dews, A. Lloyd Wnuck, R. V. Fanelli, Amos E. Light, John A. Tornaben, Stata Norton, C. H. Ellis and Edwin J. De Beer 1 II. Studies on the Relationship of Metabolic Fate and Hormonal Effects of d,l-Methadone to the Development of Drug Tolerance. Chen-Y#{252} Sung, E. Leong Way and Kenneth G. Scott 12 III. The Action of ...

the synthesis of 3-amino-1-nitroguanidine (3-anq) and 5-hydrazino tetrazole (5-ht) derivatives as new energetic materials are described. reaction of 3-anq with triethyl orthoformate leads to the formation of 3-nitramino triazole while no reaction was observed whit 5-ht. addition of nan3 to a mixture of 3-anq and triethyl orthoformate, afforded 1-nitroguanidyl tetrazole in excellent yield. on th...

In the title compound, C(5)H(8)N(3) (+)·C(7)H(5)O(2) (-), the pyridine N atom is protonated. The carboxyl-ate group of the benzoate anion is twisted away from the attached ring by 10.91 (9)°. In the crystal structure, N-H⋯O hydrogen bonds between 2,3-diamino-pyridinium cations and benzoate anions, and π-π inter-actions between the pyridinium rings [centroid-centroid distance = 3.6467 (9) Å] for...

Oxidative DNA damage is thought to be an important contributor to cancer development and to be affected by dietary constituents, so its accurate measurement is important. DNA methylation is recognized as an important mechanism affecting gene expression. In the present paper we describe an HPLC-with-electrochemical-detection procedure that allows rapid and sensitive measurement of four oxidized ...

The present work discusses the influence of additives, designated as co-adjuvants agents chemical activation, containing nitrogen on their structure, activated carbons (ACs) produced from waste polyethylene terephthalate (PET) and cork by with KOH, at 973 K. used were urea, 2-chloro-4,6-diamino-1,3,5-triazine, (2-hydroxyethyl) urea polyethylenimine. ACs, PET, only KOH presented a porous volume ...

The interaction of 2-ethoxymethylidene-3-oxo esters and their analogues with 5-aminotetrazole is an efficient synthetic approach to novel azaheterocycles. 2-Ethoxymethylidene-3-oxo esters bearing alkyl substituents react with 5-aminotetrazole to form ethyl 2-azido-4-alkylpyrimidine-5-carboxylates which are capable of subsequent nucleophilic substitution. The use of diethyl 2-ethoxymethylidenema...

Lysinuric protein intolerance (LPI) is a rare recessively inherited disease in which one of the fundamental physiological defects is in the mechanism by which diamino acids are transported by the kidney. The purpose of the present studies was to examine that mechanism in four controls and seven patients with LPI. Two types of studies were conducted. In the first set, the renal handling of l-arg...

1.1 Materials: Diamino-polyethylene glycol with MW 2000 Da (PEG2000) was purchased from Rapp Polymer. (3-Glycidoxypropyl)trimethoxysilane (GOPTS) was purchased from Fluka. EZ-Link NHSBiotin was purchased from Thermo Scientific. Hydrogen peroxide (30% solution), Acetone, Dichloromethane and N, N-Dimethylformamide were purchased from Merck. Imidazole and 2-[4-(2hydroxyethyl) piperazin-1-yl]ethane...

The proposed article relates to organic chemical synthesis and the study of bis-azourea compounds, properties new N,N1 derivatives - hexamethylene bis-[(4,41-dimethyldiphenyl)-azo-2,21-diamino) ureas]. interaction [(4,41-dimethyldiphenyl)-azo-2,21-diamino)-urea] with diisocyanate gave structure bis-[(4,41-dimethyldiphenyl)-azo-2,21-diamino)urea] was established by elemental analysis, IR PMR spe...

The present communication reports the chemistry of three linear triborane(5) compounds possessing bulky diamino substituents on the terminal boron atoms. Fluorotriborane 2 was synthesized by a reaction of boryllithium and BF(3)·OEt(2). Halogen exchange reaction of 2 took place by a treatment with ClSiMe(3) to give the corresponding chlorotriborane(5) 3. Addition of silver tetraarylborate to 3 i...