Thymidine glycol residues in DNA are biologically active oxidative molecular damage sites caused by ionizing radiation and other factors. One or two thymidine glycol residues were incorporated in 19- to 31-mer DNA fragments during automatic oligonucleotide synthesis. These oligonucleotide models were used to estimate the effect of oxidized thymidines on the thermodynamic, substrate and interfac...

ScrFI is a type II restriction-modification system from Lactococcus lactis which recognizes the nucleotide sequence 5'-CC downward arrow NGG-3', cleaving at the point indicated by the arrow, and it comprises an endonuclease gene that is flanked on either side by genes encoding two 5-methylcytosine methylases. An open reading frame (orfX) of unknown function is located immediately upstream of th...

This is a preliminary report on total mercury (THg) in core sediments (\63 lm particle size) of Sunderban mangrove wetland, northeastern part of the Bay of Bengal, India. Cold vapor atomic absorption spectrometry (CVAAS) was used for THg determination. The concentration varies from 9.8 to 535.1 ppb (ngg). Results revealed variations over premonsoon and postmonsoon month at different core depth,...

Base editors (BEs), including cytosine base editor (CBE) and adenine (ABE), have been widely used to generate irreversible nucleotide substitution in plants animals. However, their wide applications are largely hindered by the strict NG protospacer adjacent motif (PAM) sequences recognized Streptococcus pyogenes Cas9 (SpCas9) its engineered variants, such as SpCas9-NG xCas9 (Hua et al., 2019Hua...

This study aims to find out whether the Rongga language (hereinafter abbreviated as bR) is a vocal language, and reasons why bR said be language. uses qualitative method. Data was collected using observation methods, field linguistics, literature assisted by elicitation techniques, record keeping, recording. were analyzed qualitatively presented descriptively. Based on results of this it found ...

The Y chromosomal switch gene SRY, which initiates testis development during mammalian embryogenesis was recently described (l).The SRY-encoded protein contains a 79 amino acid DNA-binding motif referred to as an HMG-box (2) known to exist in other transcription factors or proteins involved in DNA bending (3). On the basis of the homology between their HMGboxes, other SRY-related genes have bee...

Stream ciphers play an important role in symmetric cryptology because of their suitability in high speed applications where block ciphers fall short. A large number of fast stream ciphers or pseudorandom bit generators (PRBGs) can be found in the literature that are based on arrays and simple operations such as modular additions, rotations and memory accesses (e.g. RC4, RC4A, Py, Py6, ISAAC etc...

The relationship of macromolecular structure to biological activity will be understood in its totality only when complete structural determinations of representative macromolecules have been made. But even then, as now, a variety of physicoand biochemical methods will necessarily be brought to bear on such problems as the nature of the forces which determine and maintain structural integrity an...