BACKGROUND Leishmaniasis is a neglected tropical parasitic diseases affecting millions of people around the globe. Quinazolines are a group of compounds with diverse pharmacological activities. Owing to their promising antileishmanial activities, some 3-aryl-2-(substitutedstyryl)-4(3H)-quinazolinones were synthesized in good yields (65.2% to 86.4%). RESULTS The target compounds were synthesiz...

quinazolinones are interesting materials because of their valuable biological effects. in this study some new 2,3-disubstituted-4(3h)quinqzolinone derivatives were synthesized from anthranilic acid in six steps by introducing a new chiral center to the aliphatic side chain of the quinazolinone. in the last step, a single acylation on the hydrazine moiety afforded final compounds. the structures...

Analysis of the functional nature of mutations can be based on comparisons of their manifestation in organisms with a deletion or duplication of a particular chromosome segment. With the use of reciprocal translocation T(16;17)43H, it is feasible to produce mice with tertiary trisomy of the proximal region of chromosome 17. The mutations on chromosome 17 we tested included brachyury (T), hairpi...

The present work describes convenient synthesis of the novel Schiff bases 4, 5 and 6 by reaction each previously synthesized quinazolinones 1, 2 3 with p-methoxybenzaldehyde. [2+2] Cycloaddition Reaction former within phenylisothiocyanate affording azatedine derivatives 7 8. Also, quinazolines 1 could be reacted α-bromoglucose tetraacetate giving peracetylated N-glycosides 9 10 which were then ...