Parkinson's disease (PD) is a neurological disorder characterized by degeneration of nigrostriatal dopaminergic (DAergic) system. Present treatment targeting to DAergic system solely ameliorated the symptoms but failed to retard the DAergic neuron degeneration, therefore new therapeutic methods aiming at preventing or delaying the neurodegenerative process are urgently needed. In the present st...

To develop novel antimycobacterial agents, a new series of thiazolidinone-azole hybrids 4a-b, 5a-b and 6-13 were designed and synthesized. Thiazolidin-4-ones (4a-b and 5a-b) were obtained by the reaction of Schiff bases and hydrazones (2a-b and 3a-b) with mercaptoacetic acid. 5-Benzylidene derivatives (6-13) were gained by treatment of 5a-b with appropriate benzaldehydes according to Knoevenage...

Neuroinflammation is an integral part of epilepsy pathogenesis and other convulsive conditions, non-steroidal anti-inflammatory drugs (NSAIDs) present a potent tool for the contemporary search design novel anticonvulsants. In paper, evaluation anticonvulsant activity potential NSAID dual COX-2/5-LOX inhibitor darbufelone methanesulfonate using scPTZ model in mice dose 100 mg/kg reported. Darbuf...

A concise and stereoselective synthesis of racemic erythro-methylphenidate (1) is described. The coupling reaction between piperidine-2-thione (3) and 2-bromo-2-phenylmethylacetate (4) afforded the -enaminocarbonyl compound 2 in 60% yield by a modified Eschenmoser sulfide contraction reaction. In most cases the bicyclic thiazolidinone 5 was produced. Diastereoselective reduction of 2 in the pre...

Benzofurans are very interesting heterocycles, which are available in nature and show a wide range of pharmacological activities. Hence, different benzofurans having 4-thiazolidinones have been synthesized for the purpose of pharmacological evaluation. The desired compounds were prepared using simple starting materials like salicylaldehyde and ethyl bromoacetate. The reaction between these comp...