In the title thio-urea derivative, C(10)H(17)N(3)O(2)S, the carboxyl group and the least-squares plane through the cyclo-hexyl ring are twisted out of the plane through the central CN(3)S residue; the respective dihedral angles are 7.18 (8) and 62.29 (4)°. The conformation about the azomethine bond [1.275 (2) Å] is E. The NH groups are anti, with one forming an intra-molecular N-H⋯N hydrogen bo...

(R)- and (S)-dichlorprop/alpha-ketoglutarate dioxygenases (RdpA and SdpA) catalyze the oxidative cleavage of 2-(2,4-dichlorophenoxy)propanoic acid (dichlorprop) and 2-(4-chloro-2-methyl-phenoxy)propanoic acid (mecoprop) to form pyruvate plus the corresponding phenol concurrent with the conversion of alpha-ketoglutarate (alphaKG) to succinate plus CO2. RdpA and SdpA are strictly enantiospecific,...

A cell-based transactivation assay was established using the mouse full-length peroxisome proliferator-activated receptor (PPAR) cDNA sequence and the positive peroxisome proliferator-responsive regulatory element (-578 to -553) of the rat acyl-CoA oxidase gene promoter. Activation of the reporter plasmid was dependent on co-transfection of the full-length PPAR cDNA, and the response was greatl...

In the title compound, C(12)H(16)N(2)O(6)S, the S atom adopts a distorted tetra-hedral geometry with an O-S-O angle of 119.76 (13)°. The nitro group is twisted by 35.34 (2)° with respect to the aromatic ring; it accepts an N-H⋯O hydrogen bond, resulting in a S(7) motif. In the crystal, N-H⋯O and O-H⋯O hydrogen bonds connect the mol-ecules into an infinite chain along the a axis. The methyl C at...

In the crystal structure of the title compound, C(16)H(15)NO(3), inter-molecular N-H⋯O hydrogen bonds link the mol-ecules into chains parallel to the b axis and pairs of inter-molecular O-H⋯O hydrogen bonds between inversion-related carb-oxy-lic acid groups link the mol-ecules into dimers. The dihedral angle between the two benzene rings is 82.4 (2)°.

Several metabolomics of polymeric flavan-3-ols have reported that proanthocyanidins are extensively metabolized by gut microbiota. 5-(3',4'-dihydroxyphenyl)-γ-valerolactone (DHPV) has been reported to be the major microbial metabolite of proanthocyanidins. We demonstrated that DHPV has stronger prevention effect on tumor necrosis factor (TNF)-α-stimulated adhesion of THP-1 human monocytic cells...

Docking and molecular dynamics simulations have been carried out to investigate the interaction of a traditional Chinese medicine, WenQingYin, with the glutamate receptor 2 (GluR2) subunit of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. Four representative drug components of WenQingYin, namely 2-(3,4-dihydroxyphenyl)-5,6,7-trihydroxy-4H-chromen-4-one (PHF), 4-hydrox...

walnut is a hardwood tree which covers a wide area of the plantation forest and gardens. the objective of this study was the separation and identification of compounds produced from pyrolysis of walnut wood at fixed bed reactor under an inert gas atmosphere (nitrogen) at 350 oc for 20 minutes. the separation and identification of compounds from bio-oil treated with n,o-bis (tri methyl sailil) t...