BACKGROUND This study sought to determine the frequency of large lipid-rich plaques (LRP) in the coronary arteries of individuals with high coronary artery calcium scores (CACS) and to determine whether the CACS correlates with coronary lipid burden. METHODS AND RESULTS Combined near-infrared spectroscopy and intravascular ultrasound was performed in 57 vessels in 20 asymptomatic individuals ...

OBJECTIVE This multicentre, randomized, double-blind, placebo-controlled parallel-group study was undertaken to investigate the efficacy, safety and tolerability of lumiracoxib (Prexige), a cyclooxygenase-2 selective inhibitor, in patients with primary osteoarthritis (OA) of the hand. METHODS The study randomized 594 patients aged > or = 18 years with symptomatic OA of the hand. Patients unde...

The relative efficacy of various types of treatment in preventing metastatic uveal melanoma is unclear. We have performed a phase I-II non-randomised trial to determine if patients with large (greater than 15 mm in diameter or greater than 5 mm in thickness) uveal melanomas would benefit from pre-enucleation irradiation. Twenty-eight patients were treated between 1978 and 1983 by means of 5 X 5...

Antireflection (AR) coatings are indispensable in numerous optical applications and are increasingly demanded on highly curved optical components. In this work, optical thin films of SiO2, Al2O3, TiO2 and Ta2O5 were prepared by atomic layer deposition (ALD), which is based on self-limiting surface reactions leading to a uniform film thickness on arbitrarily shaped surfaces. Al2O3/TiO2/SiO2 and ...

We report the first interferometric observations of the dynamics of electron–ion cavitation of relativistically self-focused intense 4 TW, 400 fs laser pulse in a He gas jet. The electron density in a channel 1 mm long and 30 mm in diameter drops by a factor of approximately 10 from the maximum value of ;8310 cm. A high radial velocity of the plasma expansion, ;3.8310 cm/s, corresponding to an ...

The present study was carried out in order to compare the effects of administration of organic (methylmercury, MeHg) and inorganic (mercury chloride, HgCl 2 ) forms of mercury on in vivo dopamine (DA) release from rat striatum. Experiments were performed in conscious and freely moving female adult Sprague-Dawley (230-280 g) rats using brain microdialysis coupled to HPLC with electrochemical det...

Ignition of Nanocomposite Thermites by Electric Spark and Shock Wave Report Title Nanocomposite 8Al ·MoO3 thermite particles were prepared using arrested reactive milling and ignited using two experimental techniques. In spark ignition, a monolayer of powder was placed on a conductive substrate and heated in air by a pulsed electrostatic discharge. In shock ignition, an individual particle was ...