Previous workshops related to aspect oriented software development, reflection organized at previous ECOOP conferences (e.g., RMA’001.and AOMMeT’012.) and conferences on the same topics (Reflection’01 and AOSD since 2002) have pointed out the growing interest on these topics and their relevance in the software evolution as techniques for code instrumentation. Very similar conclusions can be dra...

This paper presents a method for semi-autonomous hazard avoidance in the presence of unknown moving obstacles and unpredictable driver inputs. This method iteratively predicts the motion and anticipated intersection of the host vehicle with both static and dynamic hazards and excludes projected collision states from a traversable corridor. A model predictive controller iteratively replans a sta...

In this study, we identify new isoforms of the retinal phosducin and investigate the expression of the phosducin family, showing that an isoform, PhLP1, has sequence homology with Phd and Gâγ binding capability, whereas two isoforms (phosducin-like orphan proteins, PhLOPs) share sequence homology with Phd but fail to bind Gâγ. Original identification of PhLP1 and the PhLOPs was from a human ret...

Linguistics and archaeology have been, and continue to be, entwined in the discourse on the early human history of the Pacific. It is commonly assumed, explicitly or otherwise, that the bearers of the Lapita culture were speakers of Proto-Oceanic, the ancestor of the Austronesian languages of most of the Pacific. In this discursive piece, the chronological data for the location and timing of th...

T helper cells are crucial for psoriasis pathogenesis. Communication between and psoriatic keratinocytes (KCs) helps drive the Th1 Th17 response, but underlying mechanism is not well-understood. Small extracellular vesicles (sEVs) emerging mediators of intercellular communication. Here, we investigated role KC-derived sEVs in response psoriasis. We isolated characterized from KCs under normal (...

•Lanthanoids display ligand-field-like effects at room temperature•Anisotropic paramagnetic susceptibility parameters are reported for all lanthanoids•Site-specific isotope labels yield assignments of up to 1,400 ppm wide 1H-NMR spectra Lanthanoid tri-cations considered be chemically indistinguishable. A general dogma on the 4 f-electrons states that they shielded by outer electrons such do not...

The aim of present work is to develop colon specific matrix tablets of tramadol using natural almond gum as carrier. Matrix tablets of Tramadol HCl were prepared by using 30, 40, 50, 60 and 70% w/w of tablets of Almond gum as carrier by wet granulation technique. These tablets were compression coated with Eudragit S100 to prevent drug release in stomach. All formulations were evaluated for hard...