Despite aggressive treatment with radiation and chemotherapy, recurrence of glioblastoma multiforme (GBM) is inevitable. The objective of this study was to show that the blood-brain barrier (BBB), through a combination of tight junctions and active efflux transporters in the brain microvasculature, can significantly restrict delivery of molecularly targeted agents to invasive glioma cells. Tran...

Hawaii 167. Our observations confirm the hypothesis that Hawaii 167 contains a massive quantity of dust, the optical depth of which is sufficient to extinguish completely our ultraviolet view of a central, buried quasar. The submillimetre luminosity and associated dust mass of Hawaii 167 are similar to those of the ultraluminous class of infrared galaxies, supporting the existence of an evoluti...

Orthopedic surgery is common in pediatric patients because of the wide variety of bone and muscle injury or disease during childhood.These entities range from simple fractures in healthy children to complex spinal fusions in children with debilitating neuromuscular disorders. Anesthetic considerations for children with these specific disorders are covered in Chapter 5. This chapter focuses on c...

The present study was performed to evaluate the in vitro inhibitory potential of sarpogrelate and its active metabolite, M-1, on the activities of nine human cytochrome (CYP) isoforms. Using a cocktail assay, the effects of sarpogrelate on nine CYP isoforms and M-1 were measured by specific marker reactions in human liver microsomes. Sarpogrelate potently and selectively inhibited CYP2D6mediate...