نتایج جستجو برای: 30a

تعداد نتایج: 564  

Journal: :Cancer discovery 2014
Holger Moch Magdalena Lukamowicz-Rajska

Clear cell renal cell carcinoma (ccRCC), the most frequent subtype of renal cell cancer, is characterized by mutation of the von Hippel-Lindau (VHL) tumor suppressor gene, which results in stabilization of hypoxia-inducible factor (HIF) α proteins. In this issue of Cancer Discovery, Mathew and colleagues report that miR-30c-2-3p and miR-30a-3p downregulation in ccRCC promotes increased expressi...

2002
Johann Rafelski Jean Letessier

A brief summary of strangeness mile stones is followed by a chemical non-equilibrium statistical hadronization analysis of strangeness results at SPS and RHIC. Strange particle production in AA interactions at √ s NN ≥ 8.6 GeV can be understood consistently as originating from the deconfined quark–gluon plasma in a sudden hadronization process. Onset of QGP formation as function of energy is pl...

2005
Marcus Bleicher

sNN = 200 GeV within Landau’s hydrodynamical model. From the measured data on the widths of the pion rapidity spectra, we extract the sound velocity c2s in the early stage of the reactions. It is found that the sound velocity has a local minimum (indicating a softest point in the equation of state, EoS) at Ebeam = 30A GeV. This softening of the EoS is compatible with the assumption of the forma...

2013
Enrica Calura Robert Fruscio Lara Paracchini Eliana Bignotti Antonella Ravaggi Paolo Martini Gabriele Sales Luca Beltrame Luca Clivio Lorenzo Ceppi Mariacristina Di Marino Ilaria Fuso Nerini Laura Zanotti Duccio Cavalieri Giorgio Cattoretti Patrizia Perego Rodolfo Milani Dionyssios Katsaros Germana Tognon Enrico Sartori Sergio Pecorelli Costantino Mangioni Maurizio D'Incalci Chiara Romualdi Sergio Marchini

Purpose:Epithelial ovarian cancer (EOC) is oneof themost lethal gynecologic diseases, with survival rate virtually unchanged for the past 30 years. EOC comprises different histotypes with molecular and clinical heterogeneity, but up till now the present gold standard platinum-based treatment has been conducted without any patient stratification. The aim of the present study is to generate micro...

2013
Wei Hu Ning Liu Yuhua Tian Lianxue Zhang

The objective of this study is to clone and charecterize the expression of dammarenediol synthase gene and then to determine the relationship between the expression of dammarenediol synthase gene that is involved in the ginsenoside biosynthetic pathway and the ginsenoside content. A cDNA phage library was constructed from a five-year-old ginseng root. The cDNA library was screened for the damma...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2013
Enrica Calura Robert Fruscio Lara Paracchini Eliana Bignotti Antonella Ravaggi Paolo Martini Gabriele Sales Luca Beltrame Luca Clivio Lorenzo Ceppi Mariacristina Di Marino Ilaria Fuso Nerini Laura Zanotti Duccio Cavalieri Giorgio Cattoretti Patrizia Perego Rodolfo Milani Dionyssios Katsaros Germana Tognon Enrico Sartori Sergio Pecorelli Costantino Mangioni Maurizio D'Incalci Chiara Romualdi Sergio Marchini

PURPOSE Epithelial ovarian cancer (EOC) is one of the most lethal gynecologic diseases, with survival rate virtually unchanged for the past 30 years. EOC comprises different histotypes with molecular and clinical heterogeneity, but up till now the present gold standard platinum-based treatment has been conducted without any patient stratification. The aim of the present study is to generate mic...

2017
Tao Zhang Chang Liu Shi Huang Yuanping Ma Jiansong Fang Yuanneng Chen

Objective. Here, we aim to investigate the microRNA (miR) profiling in human gastric cancer (GC). Methods. Tumoral and matched peritumoral gastric specimens were collected from 12 GC patients who underwent routine surgery. A high-throughput miR sequencing method was applied to detect the aberrantly expressed miRs in a subset of 6 paired samples. The stem-loop quantitative real-time polymerase c...

Journal: :European heart journal 2014
Regalla Kumarswamy Ingo Volkmann Julia Beermann Lars Christian Napp Olga Jabs Raj Bhayadia Anette Melk Ahmet Ucar Kamal Chowdhury Johan M Lorenzen Shashi Kumar Gupta Sandor Batkai Thomas Thum

RATIONALE Many processes in endothelial cells including angiogenic responses are regulated by microRNAs. However, there is limited information available about their complex cross-talk in regulating certain endothelial functions. AIM The objective of this study is to identify endothelial functions of the pro-hypertrophic miR-212/132 cluster and its cross-talk with other microRNAs during develo...

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