نتایج جستجو برای: 3 mrna
تعداد نتایج: 1925302 فیلتر نتایج به سال:
As an important mode of suppressing gene expression, messenger RNAs containing an AU-rich element (ARE) in the 3' untranslated region are rapidly degraded in the cytoplasm. ARE-mediated mRNA decay (AMD) is initiated by deadenylation, and in vitro studies have indicated that subsequent degradation occurs in the 3'-5' direction through a complex of exonucleases termed the exosome. An alternative ...
BACKGROUND Molecular studies of the human disease transcriptome typically involve a search for genes whose expression is significantly dysregulated in sick individuals compared to healthy controls. Recent studies have found that only a small number of the genes in human disease-related pathways show consistent dysregulation in sick individuals. However, those studies found that some pathway gen...
سابقه و هدف: نروپاتی دیابت می تواند منجر به اتروفی عضلانی و ضعف در عضلات تحتانی ناشی از تخریب عصبی شود کاهش حمایت تروفیکی یکی از دلایل بروز و پیشرفت نروپاتی دیابت است. هدف از انجام پژوهش حاضر بررسی تاثیر تمرین استقامتی بر بیان mRNA نروتروفین-3 (NT-3) در عضله سولئوس موشهای صحرایی دارای نروپاتی دیابت بود. مواد و روش ها: 24 سر موش صحرایی بالغ نر نژاد ویستار به طور تصادفی در چهار گروه شش تایی: دی...
The present study was designed to investigate the inhibitory effect of 2,4 bis-[(4-ethoxyphenyl)azo] 5-(3-hydroxybenzylidene) thiazolidine-2,4-dione (TZD-OCH2CH3) on the cyclo-oxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in RAW 264.7 cells. The effects of TZD-OCH2CH3 on COX-2 and iNOS mRNA expression in LPS-activated RAW 264.7 cells ...
Introduction: It has been reported the alkaline response of pancreas to duodenal acidification is partly mediated through duodenal release of H2S, but till now the effect of duodenal acidification on gastric H2S release has not been investigated. Therefore, the present study designed to evaluate the effects of duodenal acidification on gastric H2S release and level of mRNA expression of cys...
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