We have conducted a dietary trial in 54 men and 51 women with a wide range of fasting cholesterol values to examine the use of low density lipoprotein (LDL) particle size to predict the lipoprotein response to dietary fat and cholesterol. After a 2-week low fat period, subjects were given two liquid supplements in addition to their low fat diet for 3 weeks each, one containing 31-40 g of fat an...

Steroid-secreting cultured mouse adrenal cells of the Y-l clone were shown to possess a high affinity cell surface receptor for plasma low density lipoprotein (LDL). Binding of either human or mouse LDL to the receptor was followed by the uptake of the lipoprotein and the hydrolysis of its protein and cholesteryl ester components within lysosomes. In the absence of adrenocorticotropin (ACTH). t...

Experimental and epidemiological evidence supports the hypothesis that oxidation of low density lipoprotein (LDL) appears to be important in mediating the atherogenicity of LDL. To test this hypothesis in humans, it will be necessary to perform intervention studies in large populations. We performed two studies to assess the effectiveness of supplementation with beta-carotene and vitamin E, use...

The effect of 5 days of oral nifedipine treatment (approximately 1 mg/kg per day in drinking water) on low density lipoprotein (LDL) and cholesterol accumulation in rabbit arteries was determined. Compared with control aortas, nifedipine treatment (n = 5) significantly reduced homologous 125I-tyramine cellobiose-LDL accumulation (control versus nifedipine: 45.93 +/- 4.3 versus 20.14 +/- 3.1 ng ...

Much data support a role for both low density lipoprotein (LDL) oxidation and glycation in atherogenesis. While alpha-tocopherol decreases the oxidative susceptibility of LDL, its role in decreasing LDL glycation is unclear. Hence we tested the effect of alpha-tocopherol both in vitro and in vivo on LDL oxidation and glycation. LDL was isolated after enrichment of plasma with alpha-tocopherol. ...

Objetivo: Relatar o impacto da mutação C681X no tratamento de hipercolesterolemia familiar homozigótica. Detalhamento do caso: Paciente, sexo masculino, 17 anos, com história colesterol alto (LDL-c: 760 mg/dl), xantomas tuberosos e arcos corneanos desde os sete anos. Teste genético confirmou homozigótica receptor LDL, sem alterações cardiovasculares. Pai, mãe, irmão apresentaram LDL-c >190mg...

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian Tapak Liman (Elephantopus scaber L.) terhadap High Density Lipoprotein (HDL) dan Low (LDL) serum darah broiler. dilaksanakan pada Februari—Maret 2022 di kandang ayam Jurusan Peternakan Fakultas Pertanian Universitas Lampung Laboratorium Pramita Biolab Indonesia. menggunakan metode Rancangan Acak Lengkap (RAL). 4 perlakuan 3 ulangan de...

Hypercholesterolemia is a known major risk factor in the development of athereosclerosis [29, 32, 51]. This circumstance is caused by internal homeostasis due to foods consumed. The hypercholesterolemia may be related to high cholesterol diet or regular saturated fatty acids intake [42]. The incidence of Chronic Heart Disease (CHD) remains high despite blood pressure being controlled in hyperte...

Elevated cholesteryl ester transfer protein-mediated transfer of cholesteryl ester (CE) from high-density lipoprotein (HDL) to low-density lipoprotein (LDL) may contribute to the atherogenicity of LDL in subjects with familial hypercholesterolemia (FH). To identify the major CE acceptors among LDL subspecies, we investigated the qualitative and quantitative features of CE transfer and exchange ...

Interindividual variability in low density lipoprotein (LDL) cholesterol (LDL-C) response during treatment with statins is well documented but poorly understood. To investigate potential metabolic and genetic determinants of statin responsiveness, 19 patients with refractory heterozygous familial hypercholesterolemia were sequentially treated with placebo, atorvastatin (10 mg/d), bile acid sequ...