Selected 2,6-(disubstituted)purine 2',3'-didehydro-2',3'-dideoxynucleosides and 2',3'-dideoxynucleosides were prepared and evaluated. Treatment of 5'-protected ribonucleosides with phenoxythiocarbonyl chloride and 4-(dimethylamino)pyridine, or under Schotten-Baumann conditions, gave high yields of 2',3'-O-thionocarbonates that underwent Corey-Winter elimination. Treatment of unprotected ribonuc...

The title compound, C(22)H(16)N(2), is the first example of an ynamine with H atoms bonded to the terminal C atoms. The environment around each N atom is almost planar. The distances of the N atoms from a least squares plane fitted through each N atom and the surrounding three C atoms, are 0.087 (3) and 0.041 (4) Å. The dihedral angles between these two planes and the central phenyl-ene ring ar...

An efficient and convenient protocol for synthesis of 3-hydroxy-3-indolyl-2-oxindoles and 3,3-diindolyl-2-oxindoles is presented here. The syntheses were achieved selectively under catalysis of LiClO4 whereby the products were obtained purely.

An efficient and convenient protocol for synthesis of 3-hydroxy-3-indolyl-2-oxindoles and 3,3-diindolyl-2-oxindoles is presented here. The syntheses were achieved selectively under catalysis of LiClO4 whereby the products were obtained purely.

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The authors regret that in the original Full Paper, some characterization and images of catalyst Cu/MOF-74 from previous reports were incorrectly shown main text Supporting Information. material was therefore resynthesized following reported procedure characterized anew. Figure 13 should be replaced by 1 below. FT-IR spectra (a) fresh (b) reused catalyst. new materials carried out using differe...

The membrane-bound sterol delta 24-reductase (24-reductase) catalyses anaerobic reduction of the 24(25)-enes of lanosterol and other obligatory intermediates of cholesterol biosynthesis from lanosterol. A novel assay method and properties of the 24-reductase are described. More than a 120-fold induction of the 24-reductase activity was achieved by feeding rats a diet containing 5% cholestyramin...