The increased intricacy of Intensity-Modulated-Radiation-Therapy (IMRT) delivery has created the need for a high-resolution 3D-dosimetry (three-dimensional) system capable of measuring and verifying the complex delivery. Present clinical methods are inadequate being restricted to single points (e.g., ion-chambers) or to 2D planes (e.g., film), and are labor intensive. In this paper we show that...

introduction: orthogonal radial fields are those in which the central axes are perpendicular to each other. an example of these orthogonal fields is the set of craniospinal orthogonal fields that are used for radiotherapy of medulloblastoma. craniospinal radial fields consist of two parallel-opposed fields for brain exposure and one or two posterior spinal fields for spinal cord exposure. the m...

Background: Megavoltage beams used in radiotherapy are contaminated with secondary electrons. Different parts of linac head and air above patient act as a source of this contamination. This contamination can increase damage to skin and subcutaneous tissue during radiotherapy. Monte Carlo simulation is an accurate method for dose calculation in medical dosimetry and has an important role in opt...

UNLABELLED Serotonin 1A receptors have been implicated in a variety of conditions including depression, suicidal behavior, and aggression. Dose estimates for current human studies are based on data from rat dosimetry studies. We report the biodistribution and dosimetry of the PET serotonin 1A antagonist 11C-WAY100,635 in humans. METHODS PET studies of 6 healthy human volunteers (3 male, 3 fem...

Linear accelerators used in radiation therapy treatments usually provide the capability of irradiating with different dose rates. The medical physicist may choose arbitrary the dose rate to use, although the relative biological effectiveness (RBE) varies with this physical parameter. In this work the measurements of absorbed dose of the x-ray beams from a Varian 6 MV linear accelerator CLINAC 6...

In the UK cancer is the leading cause of mortality in people under the age of 75 and accounts for one in four deaths overall. Cancer is currently the third largest NHS (National Health Service) disease programme. Radiotherapy is one of the main forms of cancer treatment, with an overall cure rate of 40 %. In this paper we review the different types of radiotherapy treatments used and we summari...

6-Deoxy-6-[(18)F]fluoro-D-fructose (6-[(18)F]FDF) is a promising PET radiotracer for imaging GLUT5 in breast cancer. The present work describes GMP synthesis of 6-[(18)F]FDF in an automated synthesis unit (ASU) and dosimetry calculations to determine radiation doses in humans. GMP synthesis and dosimetry calculations are important prerequisites for first-in-human clinical studies of 6-[(18)F]FD...

Several national and international organizations have developed various types and levels of external audits for radiotherapy dosimetry, either based on on-site review visits or using mailed dosimetry systems. Three major TLD (thermoluminescent dosimetry) networks make available postal dose audits to a large number of radiotherapy centres on a regular basis. These are the IAEA/WHO TLD postal dos...