Patient Selection Criteria Coverage eligibility for genetic testing for BRCA1 and BRCA2 mutations in cancer-affected individuals will be considered when ANY of the following criteria are met:  Individual from a family with a known BRCA1/BRCA2 mutation  Personal history of breast cancer and ≥1 of the following: o Diagnosed age ≤45 years o 2 primary breast cancers when 1st breast cancer diagnos...

The two times-cytoreductive surgery (CRS) seems to be effective treatment because it allows complete removal of widespread masses and a reduction of surgical complications for pseudomyxoma peritonei (PMP) with high PCI. The present study verified the indication and prognostic factors of two times-CRS for patients with PMP. Between 2006 and 2017, 85(22.8%) patients were programmed a two times-su...

Clonal fishes are useful tools in biology and aquaculture studies due to their isogenicity. In Japanese flounder (Paralichthys olivaceus), a group of homozygous clones was created by inducing meiogynogenesis in eggs from a mitogynogenetic homozygous diploid. As the clones reached sexual maturity, meiogynogenesis was again induced in order to produce a 2nd generation clonal group of Japanese flo...

To compare the predictive ability of primary and secondary Gleason pattern for positive surgical margins in patients with clinically localized prostate cancer and a preoperative Gleason score ≤ 6. A retrospective analysis of the medical records of patients undergone a radical prostatectomy between January 2005 and October 2010 was conducted. Patients' age, prostate volume, preoperative PSA, bio...

Purported genetic associations found in population studies require validation for confirmation. We previously reported rubella vaccine-induced immune responses and HLA associations in 346 adolescents, age 12-18 years (1st cohort), following two doses of a rubella-containing vaccine. We sought to replicate the associations discovered in that work by verifying these associations in a new cohort o...

1. p. 1035, left column, 3rd paragraph, 2nd line 10 The citation should not be to Ref. [15], but to 11 Ref. [30]; see also point 9 of this errata list. 12 • p. 1036, left column, 2nd paragraph, 2nd line 13 The citation should not be to Refs. [2,16,28, 14 29], but to Refs. [2,16,28,29,31]; see also point 15 9 of this errata list. 16 2. p. 1040, Section 3.4.2.3, 9th line 17 The command “legion na...

Using a con guration space approach, this paper develops a 2nd order mobility theory for a body, B, in frictionless quasi-static contact with rigid stationary bodies A1; ;Ad. This analysis ultimately leads to a coordinate invariant 2nd order mobility index, an integer that captures the inherent mobility of B in an equilibrium grasp. The 2nd order index di erentiates between grasps which are dee...

Using a configuration-space approach, this paper develops a novel 2nd-order mobility theory for rigid bodies in contact. A major component of this theory is a coordinate invariant 2nd-order mobility index for a body, B, in frictionless contact with finger bodies A1; ;Ak. The index is an integer that captures the inherent mobility of B in an equilibrium grasp due to second order, or surface curv...

OBJECTIVES Chemotherapy as first-/second-line treatment in different epidermal growth factor receptor (EGFR) mutation lung adenocarcinoma remains controversial. METHODS Consecutive patients were collected between 2009 and 2012. Patients were divided into two groups (1st-line chemotherapy: n = 56 and 2nd-line chemotherapy: n = 55). Their outcomes profiles were analyzed. RESULTS The overall s...