Recently, evidence was reported for the belief that a carcinogenic agent, †̃20-methyleholanthrene, could be secreted into the milk of a lactating ani mal and thereby gain entrance into the bodies of the offspring to cause an abnormally high mci dence of neoplasms (1). Further positive evidence for this mode of excretion of methyleholanthrene has now been obtained by means of ultraviolet ab sor...

Sequence alignment shows that residue Arg 284 (according to the numbering of the residues in formate dehydrogenase, FDH, from the methylotrophic bacterium Pseudomonas sp. 101) is conserved in NAD-dependent FDHs and D-specific 2-hydroxyacid dehydrogenases. Mutation of Arg 284 to glutamine and alanine results in a change of the catalytic, thermodynamic and spectral properties of FDH. In compariso...

Martin Biastoch, Tübinger Studenten im Kaiserreich. Eine sozialgeschichtliche Untersuchung (Contubemium. Beiträge zur Universitäts- und Wissenschaftsgeschichte, Bd.44), Sigmaringen (Thorbecke) 1996. 284 S.

We have investigated at the oligomeric level interactions between Aβ(25-35) and Tau(273-284), two important fragments of the amyloid-β and Tau proteins, implicated in Alzheimer's disease. We are able to directly observe the coaggregation of these two peptides by probing the conformations of early heteroligomers and the macroscopic morphologies of the aggregates. Ion-mobility experiment and theo...

A retrospective study of central nervous system (CNS) in 284 autopsy AIDS cases in Brazil (1989-2008) divided into 3 groups: A (without antiretroviral treatment: 163 cases); B (other antiretroviral therapies: 76 cases); C (HAART for 3 months or more: 45 cases). In 165 (58.1%) cases, relevant lesions were found, predominantly infections (54.2%); the most frequent was toxoplasmosis (29.9%) follow...

Background We estimated the incidence of acquired isoniazid and rifampicin resistance in rifampicin-susceptible tuberculosis in a setting of high human immunodeficiency virus type 1 (HIV-1) infection and tuberculosis coprevalence. Methods GeneXpert MTB/RIF-confirmed patients with rifampicin-susceptible tuberculosis were recruited at antituberculosis treatment initiation in Khayelitsha, South ...

Sufficient conditions are established for the asymptotic behavior of a third-order nonlinear differential equation. Our results improve on Qian’s [C. Qian, Asymptotic behavior of a third-order nonlinear differential equation, J. Math. Anal. Appl., 284 (2003), 191–205]