نتایج جستجو برای: 25k fp gene
تعداد نتایج: 1149162 فیلتر نتایج به سال:
Purpose: Pretargeted radioimmunotherapy (PRIT) using streptavidin (SAv)-biotin technology can deliver higher therapeutic doses of radioactivity to tumors than conventional RIT. However, "endogenous" biotin can interferewith the effectiveness of this approachbyblocking binding of radiolabeled biotin to SAv. We engineered a series of SAv FPs that downmodulate the affinity of SAv for biotin, while...
PURPOSE The present study was undertaken to determine whether exposure of the sclera to prostaglandin (PG)F(2alpha) or to the PGF(2alpha) analogue latanoprost acid alters mRNA for matrix metalloproteinases. METHOD Fifteen human eye bank eyes were studied. Circular pieces of sclera were either immediately preserved in a stabilization reagent or cultured in low-serum DMEM/F-12 medium. The cultu...
The genomic region of the Anticarsia gemmatalis multiple nucleocapsid nuclear polyhedrosis virus (AgMNPV) strain 2D encoding the polyhedrin gene was cloned and mapped, and a 2085 bp SphI-PstI fragment containing the gene was sequenced. The polyhedrin polypeptide of the parental isolate AgMNPV was manually sequenced, and the amino acid sequence obtained agreed with that deduced from the DNA codi...
Local anti-oncogene delivery providing high local concentration of gene, increasing antitumor effect and decreasing systemic side effects is currently attracting interest in cancer therapy. In this paper, a novel local sustained anti-oncogene delivery system, PECE thermoresponsive hydrogel containing folate-poly (ester amine) (FA-PEA) polymer/DNA (tumor suppressor) complexes, is demonstrated. F...
SUPPLEMENTARY FIGURE S1 ROC plots illustrating the Wormnet-based prediction of RNAi phenotypes. For each known phenotype, we analyzed the ability to predict genes conferring the phenotype using leave-one-out analysis. Every gene in the Wormnet was first rank-ordered by the sum of its LLS scores to all other genes with the given RNAi phenotype; we then measured the recovery of genes with the giv...
Proteases are closely associated with many pathological conditions. Efficient detection of protease activity may be useful for diagnosis, prognosis, and the development new therapeutic biomolecules. Fluorescent Resonance Energy Transfer (FRET) is defined as non-radioactive energy transfer that occurs between two fluorophores. proteins widely used in FRET biosensors because they can genetically ...
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