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The central circadian pacemaker, the suprachiasmatic nucleus (SCN), encodes day length information by mechanisms that are not well understood. Here, we report that genetic ablation of miR-132/212 alters entrainment to different day lengths and non-24 hr day-night cycles, as well as photoperiodic regulation of Period2 expression in the SCN. SCN neurons from miR-132/212-deficient mice have signif...
Pathological growth of cardiomyocytes (hypertrophy) is a major determinant for the development of heart failure, one of the leading medical causes of mortality worldwide. Here we show that the microRNA (miRNA)-212/132 family regulates cardiac hypertrophy and autophagy in cardiomyocytes. Hypertrophic stimuli upregulate cardiomyocyte expression of miR-212 and miR-132, which are both necessary and...
The Pb region is characterised by the existence of collective octupole states. Here we populated such states in Pb + Pb deep-inelastic reactions. γ-ray angular distribution measurements were used to infer the octupole character of several E3 transitions. The octupole character of the 2318 keV 17− → 14 in Pb, 2485 keV 19/2− → 13/2 in Pb, 2419 keV 15/2− → 9/2 in Pb and 2465 keV 17/2 → 11/2− in Tl...
RATIONALE Many processes in endothelial cells including angiogenic responses are regulated by microRNAs. However, there is limited information available about their complex cross-talk in regulating certain endothelial functions. AIM The objective of this study is to identify endothelial functions of the pro-hypertrophic miR-212/132 cluster and its cross-talk with other microRNAs during develo...
Newborn neurons in the dentate gyrus of the adult hippocampus rely upon cAMP response element binding protein (CREB) signaling for their differentiation into mature granule cells and their integration into the dentate network. Among its many targets, the transcription factor CREB activates expression of a gene locus that produces two microRNAs, miR-132 and miR-212. In cultured cortical and hipp...
Considering the critical roles of miR-132/212 participated in central nervous system, many researches started to explored the contributions of miR-132/212 to epilepsy and achieve something worthwhile. Further illuminates all the genes targeted by miR-132/212 may be a valuable means for us to completely understand the working mechanism playing in epilepsy, by which it can influence diverse biolo...
Arteriogenesis is a complicated process induced by increased local shear-and radial wall-stress, leading to an increase in arterial diameter. This process is enhanced by growth factors secreted by both inflammatory and endothelial cells in response to physical stress. Although therapeutic promotion of arteriogenesis is of great interest for ischaemic diseases, little is known about the modulati...
Problem 1 (a) We will compute theH2 norm ofG using state-space methods (see Section 2.6 in DFT). We begin by finding a minimal state-space representation of the system with transfer function G(s). Assuming u(0) = y(0) = 0 as usual, we have: sy(s) + 2sy(s) + sy(s) + y(s) = u(s) ⇔ ... y (t) + 2ÿ(t) + ẏ(t) + y(t) = u(t) Defining x1 = y, x2 = ẏ, x3 = ÿ, the corresponding state-space representation ...
A class of r.e. degrees, called the array nonrecursive degrees, previously studied by the authors in connection with multiple permitting arguments relative to r.e. sets, is extended to the degrees in general. This class contains all degrees which satisfy a 00 > (a 0 0) 0 (i.e. a 2 GL 2) but in addition there exist low r.e. degrees which are array nonrecursive (a.n.r.). Many results for GL 2 deg...
Biochemical measurements were carried out on 20 workers entering employment in a lead industry. Blood lead (Pb-B) urinary delta-aminolevulinic acid (ALA), and coproporphyrin (CP) levels were determined before entry and then at approximately weekly intervals for the first 12 weeks of employment. Levels of blood lead began to increase in all men within one week rising from an average pre-employme...
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