The mean incidence of colorectal carcinoma in persons under age 40 in Sweden is 1.74/100,000/year. Over a 30-year period, 1950 through 1979, 1061 patients with colorectal carcinoma were seen, 48 of whom where under age 40 (21 to 39 years) and in this study were compared with older patients. Carcinoma was superimposed upon ulcerative colitis in 18 patients. All patients treated for palliation di...

We compared the safety and efficacy of allogeneic stem cell transplantation (allo-SCT) after reduced-intensity conditioning using either unrelated umbilical cord blood (UCB) donors or matched-sibling donors (MSDs) for 21 adults at high risk with advanced Hodgkin lymphoma (UCB, n = 9; MSD, n = 12). Both groups were comparable except for younger age in the UCB cohort (median, 28 vs 42 years; P = ...

Epidermal growth factor receptor (EGFR), a transmembrane tyrosine kinase receptor, plays important roles in various cancers. In nonsmall cell lung cancer (NSCLC), EGFR mutations cluster around the ATP-binding pocket (exons 18-21) and some of these mutations activate the kinase and induce an increased sensitivity to EGFR-tyrosine kinase inhibitors. Nevertheless, data of EGFR mutations in HCC are...

To test the hypothesis that dobutamine-induced myocardial ischemia causes early-systolic asynchrony predominantly in the regional left ventricular wall, color kinesis (CK) images during dobutamine stress echocardiography (DSE) were recorded in 13 patients with coronary artery disease and in 10 patients without, all of whom showed normal wall motion at rest. Based on the visual interpretation of...

.......................................................................................................... 1 Populärvetenskaplig sammanfattning ................................................................ 3 List of papers ................................................................................................... 5 Abbreviations ..........................................................

The large subunit of phage lambda terminase, gpA, the gene product of the phage A gene, interacts with the small subunit, gpNul, to form functional terminase. Terminase binds to lambda DNA at cosB to form a binary complex. The terminase:DNA complex binds a prohead to form a ternary complex. Ternary complex formation involves an interaction of the prohead with gpA. The amino terminus of gpA cont...

Introduction: Lack of sleep duration is one the risk factors that cause excess body mass index (BMI). One mechanisms are by regulating an increase in appetite and reducing energy used. This study aimed to identify relationship between BMI young adults.Methods: descriptive-analytic observational with cross-sectional design was conducted on 70 respondents aged 18-25 years old. The primary outcome...

Oncogenic RET alterations are targetable markers in pts with TC. In the phase I/II ARROW trial (NCT03037385; data cutoff 12 Apr 2021; intention-to-treat [ITT] population), pralsetinib at 400 mg once daily (QD) induced overall response rates (ORR) of 51% RET-mutant medullary TC (RETm MTC) previously treated cabozantinib and/or vandetanib (C/V), 72% treatment-naïve RETm MTC, and 86% fusion-positi...