UNLABELLED BACKGROUND Enhancing CPG acceptance and implementation can play a major role in the development and establishment of emergency medicine as a specialty in many parts of the world. A Guideline International Network special interest group established to support collaboration to improve uptake of clinical practice guidelines (CPGs) across the emergency care sector conducted an interna...

It was reported that IL-17 had been detected in the inflammatory infiltrates of patients with DM (dermatomyositis). In this study, we investigated the frequency of Th17 cells and the expression of microRNA-206 (miR-206) in DM patients. Firstly, we observed that the frequency of Th17 cells and the expression of transcription factors were increased significantly in the PBMCs of DM patients. Secon...

Lead isotope ratios are widely used to identify original sources of Pb in the environment. Such source apportionment depends on the ability to distinguish potential sources on the basis of their isotopic composition. However, almost all terrestrial Pb is co-linear in some of the plots i.e. (206)Pb/(208)Pb versus (206)Pb/(207)Pb and (206)Pb/(204)Pb versus (206)Pb/(207)Pb commonly presented in th...

MicroRNAs (miRNAs) constitute of a class small non-coding RNAs that are involved in post-transcriptional gene regulation and have important regulatory roles in many fundamental biological processes. A small number of miRNAs predominantly expressed in muscle tissue have been found to play critical role in myogenesis, muscle growth, cardiac function and muscle hypertrophy. In the present study, t...

MicroRNAs (miRNAs) constitute of a class small non-coding RNAs that are involved in post-transcriptional gene regulation and have important regulatory roles in many fundamental biological processes. A small number of miRNAs predominantly expressed in muscle tissue have been found to play critical role in myogenesis, muscle growth, cardiac function and muscle hypertrophy. In the present study, t...

MicroRNAs (miRNAs) constitute of a class small non-coding RNAs that are involved in post-transcriptional gene regulation and have important regulatory roles in many fundamental biological processes. A small number of miRNAs predominantly expressed in muscle tissue have been found to play critical role in myogenesis, muscle growth, cardiac function and muscle hypertrophy. In the present study, t...

Neuropathic pain (NP), chronic pain resulted from dysfunction or diseases of the somatosensory nervous system, is a major challenge to currently available clinical therapy of peripheral nerve injury. Although there are significant improvements in drug and surgical therapy, the efficiency of the therapeutic approach for NP is low. And the molecular mechanisms of NP maintenance are still not clea...

Expression of the oncogene hepatocyte growth factor receptor (MET) and phosphorylation of the MET protein have been associated with both primary and acquired resistance to tyrosine kinase inhibitors (TKIs) used in therapy targeting the epidermal growth factor receptor (EGFR) in patients with non-small cell lung cancers (NSCLCs). Therefore, simultaneous inhibition of both of these receptor tyros...

PURPOSE Doxorubicin has shown efficacy especially in combination treatment for the treatment of multiple myeloma; however, its side effects limit its use. INNO-206 is an albumin-binding prodrug of doxorubicin, which is released from albumin under acidic conditions. Because INNO-206 has not been previously evaluated in any hematologic malignancy, we determined its anti-multiple myeloma effects. ...

MicroRNA-206 (miR-206) is known to regulate cell proliferation and migration and is involved in various types of cancer. However, the role of miR-206 in human hepatocellular carcinoma (HHC) has not been previously reported. In the present study, the expression of Notch3 in HCC and adjacent non-neoplastic tissue was immunohistochemically assessed on formalin-fixed, paraffin-embedded sections. mi...