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ساختار مشتقات پیپرازین نقش گسترده ای را در زمینه های دارویی و تاثیرات بیولوژیک بر بدن موجودات زنده نظیر انسان دارند, از ترکیبات دارویی در این زمینه می توان به ایمیتانیب بعنوان یک داروی موثر ضدسرطان اشاره نمود (capdeville et al., 2002). علاوه بر این درسالهای اخیر، حلقه پیپرازین در ساختار ترکیبات دارای اثرات دارویی و زیستی مانند ترکیبات بازدارنده استیل کوآ-کربوکسیلاز (bourbeau et al., 2013) ، باز...
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Extended abstract 1. Introduction Soil erosion is a major environmental threat worldwide. This three-stage process including detachment, transportation and sedimentation of soil particle by runoff affects natural and agricultural areas of Iran. Soil erosion has many off-site and on-site effects such as sediment deposition in the lake of dam and channels, transportation of nutrients and contam...
Dental disease is the number one clinical problem in small animal practices,[1] And thus oral pathology is exceedingly common in small animal patients. In addition, there is a very wide variety of pathologies that are encountered within the oral cavity. These conditions often cause significant pain and/or localised, regional and systemic infection.[2]</sup...
Season is the natural pattern of change in nature, which is related to the movement of the sun, the temperature cycle, the life cycle of the earth (phenology) and human culture. In astronomical and climatic seasons, a year divided into four seasons, spring, and summer, autumn and winter (Alsop, 2005), (Trenberth, 1983). Season is a period of the year with a homogeneous climate (Alsop, 1989), th...
Mammalian aging results from a replicative decline in the function of somatic stem cells and other self-renewing cells. Recent studies (Monzen et al., 2008; Nishino et al., 2008; Sanna et al., 2008; Weedon et al., 2008) link a chromatin-associated protein, HMGA2, to development, height, and mouse stem cell aging during late fetal development and young adulthood.
The term "Internet of Things (IoT)" expresses a huge network of smart and connected objects which can interact with other devices without our interposition. Radio frequency identification (RFID) is a great technology and an interesting candidate to provide communications for IoT networks, but numerous security and privacy issues need to be considered. In this paper, we analyze the security and ...
بیماری مالتیپل اسکلروزیس (ms) از شایع ترین بیماری های نورولوژیک در انسان و شایع ترین بیماری منجر به ناتوانی در جوانان ذکر شده (1998 werring & thompson,) که با التهاب بافتی و آپوپتوز سلول های عصبی همراه می باشد. در ابتدا میلین تخریب شده و سلول های تولید کننده میلین یا الیگودندروسیت ها در مراحل بعدی آسیب می بینند (et al., 2006 cudrici). مکانیسم های پاتوژنیک بیماری به طور کامل شناخته نشده است اما ...
Regarding our article on the association of androgen deprivation therapy (ADT) with increased Alzheimer’s disease risk, Bowen et al, Froehner and Wirth, Leow et al, and Brady et al highlight a number of significant considerations that will prove important in the design of future studies that investigate the association of ADT and Alzheimer’s disease. We agree with Bowen et al and Leow et al tha...
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