In order to improve the anticancer activity of isocorydine (ICD), ten isocorydine derivatives were prepared through chemical structure modifications, and their in vitro and in vivo activities were experimentally investigated. 8-Amino-isocorydine (8) and 6a,7-dihydrogen-isocorydione (10) could inhibit the growth of human lung (A549), gastric (SGC7901) and liver (HepG2) cancer cell lines in vitro...

Four new steroidal glycosides such as 3-O-6-deoxy-3-O-methyl-β-D-allopyranosyl-(1 → 4)-β-D-oleandropyranosyl-(1 → 4)-β-D-cymaropyranosyl-(1 → 4)-β-D-cymaropyranoside-12-β-tigloyl-14-β-hydroxy-17-β-pregnane (1), 3-O-6-deoxy-3-O-methyl-β-D-allopyranosyl-(1 → 4)-β-D-oleandropyranosyl-(1 → 4)-β-D-cymaropyranosyl-(1 → 4)-β-D-cymaropyranoside-12-β-(2'-amino)-benzoyl-14-β-hydroxy-17-β-pregnane (2), 3-...

Azaphilones which can be isolated from various natural resources like fungi and plant have range of potent biological activities that can be exploited against various diseases. Structure of numerous azaphilones has already been described. The present review talks about activities of azaphilones like anti-cancerous, anti-HIV, anti-nematicidal, anti-bacterial, anti-fungal which have been extensiv...

Marine bioresources are a valuable source of bioactive compounds with industrial and nutraceutical potential. Numerous clinical trials evaluating novel chemotherapeutic agents derived from marine sources have revealed novel mechanisms of action. Recently, marine-derived bioactive peptides have attracted attention owing to their numerous beneficial effects. Moreover, several studies have reporte...

We present a system for automatic people tracking and activity recognition. This video includes the contribution of 3 papers over 2 years [1], [2], [3]. We show results on many sequences, including clips from a feature-length film and historical sports footage (all tracked completely automatically). We show results that utilize the tracker to obtain 3D reconstructions and activity descriptions ...

Marine microorganisms widely distributed on our oceans of the earth and emerging as the great source for the discovery of natural products. Marine Actinomycetes are virtually unlimited sources of novel compounds with many therapeutic applications and hold a prominent position due to their diversity and proven ability to produce novel bioactive compounds. Actinomycetes represent a high proportio...

Natural products have been regarded as important sources that could produce potential chemotherapeutic agents. In the search for new bioactive entities, investigations were expanded to marine habitats. Mankind has known for the last several thousand years that marine organisms contain substances capable of potent biological activity. However, the first serious investigation of marine organisms ...