Rats made diabetic with alloxan have been shown to excrete less Nmethylnicotinamide than normal rats when given test doses of tryptophan (2). The present investigation was designed to determine the nature of the enzymatic alteration responsible for the difference between the two groups of animals. A deficiency in one or more of the enzymes needed for the conversion of tryptophan to nicotinic ac...

OBJECTIVE This study tested the hypothesis that supplementation of chromium picolinate (CrPic), 200 microg Cr/d, compared with an equivalent amount of picolinic acid (1720 microg) in CrPic and placebo, decreases body weight, alters body composition, and reduces iron status of women fed diets of constant energy and nutrients. METHODS We fed 83 women nutritionally balanced diets, used anthropom...

In the title cocrystal, [Ni(C(11)H(10)N(3)O(2))(2)]·[Ni(NCS)(2)(C(11)H(11)N(3)O(2))(H(2)O)], both Ni(II) ions are in disorted octa-hedral coordination environments. One Ni(II) ion is coordinated by four N atoms and two O atoms from two tridentate 6-(3,5-dimethyl-1H-pyrazol-1-yl)picolinate (DPP) ligands, while the other Ni(II) ion is coordinated by a tridentate 6-((3,5-dimethyl-1H-pyrazol-1-yl))...

It has been suggested that picolinic acid (PIC), an endogenous metabolite of l-tryptophan, possesses neuro-protective and anti-proliferative effects within the CNS. However, the literature surrounding PIC is limited, and its exact endogenous function is not known. Picolinic acid is produced via the kynurenine pathway which has been implicated in the pathogenesis of a range of neuro-inflammatory...

A new series of highly efficient Ir(III) complexes, (DPQ)2Ir(pic-N-O), (F4PPQ)2Ir(pic-N-O), (FPQ)2Ir(pic-N-O), and (CPQ)2Ir(pic-N-O) were synthesized for phosphorescent organic light-emitting diodes (PhOLEDs), and their photophysical, electrochemical, and electroluminescent (EL) properties were investigated. The Ir(III) complexes, including picolinic acid N-oxide (pic-N-O) ancillary ligand, are...

In order to enhance the charge balance of organic near infrared (NIR) electroluminescent devices, an ancillary ligand pic-SCz which was covalently linking bipolar group SCz (composed PS (S) and tBuCz (Cz)) pic (SCz=3,6-di-tert-butyl-9-(4-(phenylsulfonyl)phenyl)-9H-carbazole; = phenyl sulfone; 3,6-di-tert-butylcarbazole; pic= 2-picolinic acid) developed for iridium (III) complex (TPA-BTz-Iq)2Ir(...

A number of manganese-based catalysts employing ligands whose structures incorporate pyridyl groups have been reported previously to achieve both high turnover numbers and selectivity in the oxidation of alkenes and alcohols, using H(2)O(2) as terminal oxidant. Here we report our recent finding that these ligands decompose in situ to pyridine-2-carboxylic acid and its derivatives, in the presen...

The geometrical structures and photophysical properties of Ir(4,6-dFppy)₂(pic) (FIrpic) and its derivative (o-FIr, m-FIr, p-FIr) with dimethylamine substituted at the picolinic acid (N∧O) ligand were fully investigated by density functional theory and time-dependent density functional theory. The simulated electronic structure, as well as absorption and emission spectra of FIrpic are in good ag...

Recent studies have suggested a role for aminoacid catabolites as important regulators of macrophage (Mphi) activities. We reported previously that picolinic acid (PA), a tryptophan catabolite produced under inflammatory conditions and a costimulus with IFNgamma of Mphi effector functions, is a selective inducer of the Mphi inflammatory protein-1alpha (MIP-1alpha) and -1beta (MIPs), two CC-chem...