Nanoparticles composed of poly(alkyl cyanoacrylate) (PACA) have shown great promise due to their biodegradability and high drug loading capacity. Development optimal PACA nanocarriers requires detailed analysis the overall cellular impact exerted by variants. We here perform a comprehensive comparison cabazitaxel (CBZ)-loaded three different monomers, i.e. poly(n-butyl (PBCA), poly(2-ethylbutyl...

BACKGROUND There has been a steady increase in the number of cases of ciprofloxacin-resistant Pseudomonas aeruginosa (CRPA) otorrhea; this is a growing medical concern. For otological surgery in children, octylcyanoacrylate can be an alternative method of closure for surgical incisions. Recent in vitro studies have shown that octylcyanoacrylate is effective as an antimicrobical barrier. To date...

Background: The eyes are important anatomical structures in the aesthetic whole of the face. A person’s gaze communicates aspects of their personality and feelings. This study evaluated the effect of blepharoplasty on the patients’ self-esteem. Methods: From May 2006 to April 2007, 49 female patients aged 30 to 40 years (mean, 34 years) were subjec ted to blepharoplasty. In the upper eyelids, w...

For about two decades, investigators around the world have been trying to develop a safe, 95 percent effective method of nonsurgical female sterilization that could be performed under local anesthesia on an outpatient basis by nonphysicians, preferably after only a brief training period. Such a method has been called vital for meeting the worldwide demand for voluntary sterilization, since it i...

OBJECTIVES To investigate experimentally the possible histopathological effects of ethyl 2-cyanoacrylate glue when used as a tissue adhesive in cardiovascular and thoracic surgery. METHODS Sprague-Dawley rats were used for this study. For histopathological investigation, a study group of 144 rats in which intentionally produced lesions in myocardium (n=36), ascending aorta (n=36), lung (n=36)...

BACKGROUND Urethrocutaneous fistulae (UCFs) represent one of the most frequent causes of morbidity after urethroplasty. Hypospadias can be repaired using different surgical techniques, but-regardless of technique-the incidence of UCF ranges between 10% and 40%. Surgical repair of UCF remains the treatment of choice, even if some patients need further surgery because of recurrences. Cyanoacrylat...

Objective Synthetic adhesives are used by various medical specialties, especially in surgery; however, studies reporting their use in orthopedic practice are scarce. The aim of this study was to compare the results in using ethyl-2-cyanoacrylate or butyl-2-cyanoacrylate in the treatment of fractures in rats. Methods This was an experimental prospective controlled study in 90 rats, with humeru...