In a recent paper, Gilman and Philips (1) pointed out that the P-chloroethyl vesicants are extremely toxic compounds which have specific effects on the bone marrow, lymphoid tissues, and the intestinal mucosa. In addition, the systemic injury produced by these mustards causes a series of complex biochemical and physiological changes in the body. This investigation was undertaken to determine th...

The appearance of 'filler syllables' (called here PAEs, for Prefixed Additional Elements) in the late single-word period is analysed in relation to the emergence of grammatical morphemes, by confronting data from the longitudinal study of one child acquiring French, video-recorded between 1;3.2 and 2;2.6, with four hypotheses making different claims about the kind of language knowledge underlyi...

Evolutionary algorithms have been widely used to solve large and complex optimisation problems. Cultural algorithms (CAs) are evolutionary algorithms that have been used to solve both single and, to a less extent, multiobjective optimisation problems. In order to solve these optimisation problems, CAs make use of different strategies such as normative knowledge, historical knowledge, circumstan...

Cation (CEMs) and anion exchange membrane (AEMs) are commonly used in microbial fuel cells (MFCs) to enhance Coulombic efficiencies (CEs) by reducing the flux of oxygen through the cathode to bacteria on the anode. AEMs typically work better than CEMs, but in initial experiments we observed the opposite using a membrane electrode assembly MFC. The reason was identified to be membrane deformatio...

The development of new anticancer agents with lower toxicity, higher therapeutic index, and weaker tendency to induce resistant phenotypes in tumor cells is a continuous challenge for the scientific community. Toward that end, we showed previously that a new class of soft alkylating agents designed as phenyl-3-(2-chloroethyl)ureas (CEUs) inhibits tumor cell growth in vitro and that their effici...

The polymerization of N-carboxyglycine anhydride has been used to identify potential inhibitors of protein synthesis and hence of cancers. Polymerization inhibition was observed wi th N-me thylbis(2.chloroethyl)amine HC1, busulfan, I ,9-dimethylsulfonyloxynonane, phenyl isocyanate, etc. (14), tris(2-chloroethyl)amine HC1 (7), and chiorambudil (G. E. Moos and J. B. Morrison, unpublished data). I...

The development of new anticancer agents with lower toxicity, higher therapeutic index, and weaker tendency to induce resistant phenotypes in tumor cells is a continuous challenge for the scientific community. Toward that end, we showed previously that a new class of soft alkylating agents designed as phenyl-3-(2-chloroethyl)ureas (CEUs) inhibits tumor cell growth in vitro and that their effici...