Electro analysis of 2-Aminothiazole (2-AT) by a low cost poly Glycine modified Pencil Graphite Electrode (poly Gly/PGE) was studied using of cyclic voltammetric (CV) and differential pulse voltammetric (DPV) techniques. The optimal experimental conditions to determine 2-AT was setup by the variation of the current with scan rate, concentration and pH. Electrochemical performance of the 2-AT at ...

An efficient methodology for the preparation of 2-aminothiazoles is achieved by one-pot reaction of methylcarbonyls, thiourea and iodine in the presence of an aluminum oxide nanoparticle as an active nanocatalyst at 85 °C in DMSO solvent. Al2O3 nanoparticles have been prepared via co-precipitation method and their structures were confirmed using Fourier transform infrared radiation (FT-TR), X-r...

Thirty-two heterocyclic compounds, including 24 nitroheterocycles, 7 aminoheterocycles and derivatives, and 1 thiophene lacking a nitro group, were tested for mutagenic activity in Salmonella typhimurium TA 98 and TA 100. All the nitroheterocycles (11 new), including nitrofurans, nitrothiophenes, nitropyrroles, and 1 nitroimidazole, were mutagenic in TA 100; 13 were also mutagenic in TA 98. 5-N...

The most prevalent cystic fibrosis transmembrane conductance regulator (CFTR) mutation causing cystic fibrosis, DF508, impairs folding of nucleotide binding domain (NBD) 1 and stability of the interface between NBD1 and the membranespanning domains. The interfacial stability defect can be partially corrected by the investigational drug VX-809 (3-[6-[[[1-(2,2difluoro-1,3-benzodioxol-5-yl)cyclopr...