نتایج جستجو برای: 17f

تعداد نتایج: 626  

Journal: :Clinical and molecular allergy : CMA 2016
Letizia Lombardelli Federica Logiodice Maryse Aguerre-Girr Ornela Kullolli Herman Haller Ysabel Casart Alain Berrebi Fatima-Ezzahra L'Faqihi-Olive Valérie Duplan Sergio Romagnani Enrico Maggi Daniel Rukavina Philippe Le Bouteiller Marie-Pierre Piccinni

BACKGROUND Trophoblast expressing paternal HLA-C antigens resemble a semiallograft, and could be rejected by maternal CD4+ T lymphocytes. We examined the possible role in human pregnancy of Th17 cells, known to be involved in allograft rejection and reported for this reason to be responsible for miscarriages. We also studied Th17/Th1 and Th17/Th2 cells never investigated before. We defined for ...

2017
Sophie Glatt Eric Helmer Birgit Haier Foteini Strimenopoulou Graham Price Pavan Vajjah Olivier A. Harari John Lambert Stevan Shaw

AIMS To assess safety, pharmacokinetics (PK) and clinical efficacy of bimekizumab (formerly UCB4940), a novel humanized monoclonal antibody and dual inhibitor of interleukin (IL)-17A and IL-17F, in subjects with mild plaque psoriasis. METHODS Randomized, double-blind, first-in-human study of bimekizumab in 39 subjects who received single-dose intravenous bimekizumab (8-640 mg) or placebo (NCT...

2015
Seys Sven Hans Scheers Gudrun Marijsse Ellen Dilissen Annelies Van Den Bergh Pieter Goeminne Paul Van den Brande Jan Ceuppens Lieven Dupont Dominique Bullens

Results Cubic Clustering Criterion, pseudo F and t statistics revealed a twoand a six-cluster model. The first cluster (n=23) was found in both models and consists of patients who present with an “IL-5-high and IL-17F-high” profile. Patients with an “IL-4or IL-13-high” profile did not cluster in one single group. In the six-cluster model, the “IL-17F-low” group was divided into 5 separate clust...

2015
Haiyan Wang Mingzhen Guo Fenghua Liu Jingli Wang Zheng Zhou Jing Ji Yuanhua Ye Weiqing Song Shiguo Liu Bo Sun Elizabeth W Triche

Previous studies have suggested an important role for IL-17, mainly secreted by Th17 cells, in the development of systemic inflammation in preeclampsia (PE). This study therefore investigated the association between genetic variants in IL-17A, IL-17F, and IL-17RA and susceptibility to PE in Chinese Han women. We recruited 1,031 PE patients and 1,298 controls of later pregnant women, and used Ta...

2011
Paméla Gasse Nicolas Riteau Rachel Vacher Marie-Laure Michel Alain Fautrel Franco di Padova Lizette Fick Sabine Charron Vincent Lagente Gérard Eberl Marc Le Bert Valérie F. J. Quesniaux François Huaux Maria Leite-de-Moraes Bernhard Ryffel Isabelle Couillin

BACKGROUND Idiopathic pulmonary fibrosis is a devastating as yet untreatable disease. We demonstrated recently the predominant role of the NLRP3 inflammasome activation and IL-1β expression in the establishment of pulmonary inflammation and fibrosis in mice. METHODS The contribution of IL-23 or IL-17 in pulmonary inflammation and fibrosis was assessed using the bleomycin model in deficient mi...

Journal: :Immunological reviews 2008
Yoichiro Iwakura Susumu Nakae Shinobu Saijo Harumichi Ishigame

T-helper 17 (Th17) cells are a newly discovered CD4(+) helper T-cell subset that produces interleukin-17A (IL-17A) and IL-17F. IL-17A plays important roles in allergic responses such as delayed-type hypersensitivity, contact hypersensitivity, and allergic airway inflammation. IL-17A promotes inflammation by inducing various proinflammatory cytokines and chemokines, recruiting neutrophils, enhan...

Journal: :Journal of immunology 2011
Xin Zhang Yazhong Tao Luigi Troiani Silva Markovic-Plese

Subsequent to the clinical trial of simvastatin in patients with relapsing remitting multiple sclerosis (RR MS), which demonstrated the ability of simvastatin to inhibit new inflammatory CNS lesion formation, the current in vitro study has characterized the mechanisms through which simvastatin inhibits Th17 cell differentiation. The anti-inflammatory effects of statins are mediated by the inhib...

2012
Christian J. Lechner Beate Grüner Xiangsheng Huang Wolfgang H. Hoffmann Peter Kern Peter T. Soboslay

Alveolar Echinococcosis (AE) caused by the cestode Echinococcus multilocularis, is a severe helminth infection of man, where unrestricted parasite growth will ultimately result in organ failure and fatality. The tissue-infiltrative growth of the larval metacestode and the limited efficacy of available drugs complicate successful intervention in AE; patients often need life-long medication, and ...

Journal: :Blood 2014
Elena Boggio Nausicaa Clemente Anna Mondino Giuseppe Cappellano Elisabetta Orilieri Casimiro L Gigliotti Erika Toth Ugo Ramenghi Umberto Dianzani Annalisa Chiocchetti

In autoimmune/lymphoproliferative syndrome (ALPS), defective Fas death receptor function causes lymphadenomegaly/splenomegaly, the expansion of T-cell receptor αβ(+) CD4/CD8 double-negative T cells, and frequent development of hematologic autoimmunity. Dianzani autoimmune lymphoproliferative disease (DALD) has a similar phenotype but lacks the expansion of double-negative T cells. This work sho...

Journal: :Journal of immunology 2015
Shan Lu Hequan Li Rundi Gao Xuan Gao Fei Xu Qing Wang Guohua Lu Dajing Xia Jianying Zhou

We previously demonstrated an essential role of Th17 cells in excessive mucous secretion and airway smooth muscle proliferation in a prolonged OVA-challenged C57BL/6 mouse model. However, the impact of Th17 cells in vascular remodeling, another characteristic feature of airway remodeling in asthma, remains elusive. This issue was further investigated in this study. The time-course experiments s...

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