From the ‡Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, Missouri 63110, the §Department of Medicine, Karolinska Institute, 171 77 Stockholm, Sweden, the ¶Department of Microbiology and Immunology, Stanford University, Stanford, California 94305, ‡‡Swedish Institute for Infectious Disease Control, 171 82 Solna, Sweden, and §§AstraZeneca Re...

Adaptive Mutation: How Growth under Selection Stimulates Lac Reversion by Increasing Target Copy Number John R. Roth* and Dan I. Andersson Microbiology Section, University of California, Davis, Davis, California 95616, and Department of Bacteriology, Swedish Institute for Infectious Disease Control, S-171 82 Solna, and Microbiology and Tumour Biology Center, Karolinska Institute, S-171 77, Soln...

Primary clinical features Retinitis pigmentosa (rod-cone dystrophy) Obesity Polydactyly Hypogonadism Intellectual disability/cognitive impairment Renal abnormalities Secondary clinical features Diabetes mellitus type II Cardiovascular problems Hearing loss Speech deficiency Behavioral problems Craniofacial dysmorphism Short stature Hepatic involvement Eye abnormalities Ataxia Dental and palatal...

PURPOSE Patients with adult acute myeloid leukemia (AML) with intermediate cytogenetics remain a heterogeneous group with highly variable individual prognoses. New molecular markers could help to refine cytogenetic stratification. EXPERIMENTAL DESIGN We assessed P-glycoprotein (Pgp) activity and Flt3 internal tandem duplication (ITD+) because of their known prognostic value and because they m...

PAGE INTRODUCTION. ...... .......................................................... 163 Chemical composition of pollen and seed. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 166 Preparation of starches in pure form from endosperm and pollen. ....................... 171 Form of the starch grains from endosperm and pollen.. . . . . . . . . . . . . . . . ....

INTRODUCTION Information about paediatric in-hospital antimicrobial usage and prescribing patterns to guide improvement strategies is scant. We aim to use an evaluation of the prevalence and appropriateness of antimicrobial prescription to identify antimicrobial stewardship priorities in children. METHODS A cross-sectional point study was performed on hospitalised paediatric patients in a Spa...

We have collected one-dimensional raster-scan observations of the active star-forming region Sharpless 171 (S171), a typical H ii region-molecular cloud complex, with the three spectrometers (LWS, SWS, and PHT-S) on board ISO. We have detected 8 far-infrared fine-structure lines, [O iii] 52 µm, [N iii] 57 µm, [O i] 63 µm, [O iii] 88 µm, [N ii] 122 µm, [O i] 146 µm, [C ii] 158 µm, and [Si ii] 35...