The management of neuropathic pain is still a major challenge because of its unresponsiveness to most common treatments. Curcumin has been reported to play an active role in the treatment of various neurological disorders, such as neuropathic pain. Curcumin has long been recognized as a p300/CREB-binding protein (CBP) inhibitor of histone acetyltransferase (HAT) activity. However, this mechanis...

Curcumin, a bioactive component of turmeric, which is a commonly used spice and nutritional supplement, is isolated from the rhizomes of Curcuma longa Linn. (Zingiberaceae). In recent years, the potential pharmacological actions of Curcumin in inflammatory disorders, cardiovascular disease, cancer, Alzheimer’s disease and neurological disorders have been shown. However, the clinical application...

Curcumin, a derivative of the plant Curcuma longa, is used extensively in the food industry. It is a major component of curry powder, and research has shown that curcumin may prevent cancer and other chronic diseases. We have developed a robust automated analytical method for the determination of curcumin in plasma and urine. The method involves extracting the curcumin from 0.2 ml sample volume...

objective(s): the effects of curcuma longa (c. longa) and curcumin on total and differential wbc count and oxidant, antioxidant biomarkers, in rat model of asthma were evaluated. materials and methods: total and differential wbc count in the blood, no2, no3, mda, sod, cat and thiol levels in serum were examined in control, asthma, asthmatic rats treated with c. longa (0.75, 1.50, and 3.00 mg/ml...

Taurolithocholate (TLC) produces cholestasis by inhibiting biliary solute secretion in part by retrieving MRP2 from the plasma membrane (PM). Tauroursodeoxycholate (TUDC) and cAMP reverse TLC-induced cholestasis by inhibiting TLC-induced retrieval of MRP2. However, cellular mechanisms for this reversal are incompletely understood. Recently, we reported that TLC decreases PM-MRP2 by activating P...

The curcumin is part of the curcuminoids family. Present in spice turmeric a vegetable alkaloid obtained from Curcuma longa. Many studies have been carried out to describe multiple biological actions curcumin. positive antidepressant and anti-anxiety effects are most likely due its ability normalize specific physiological mechanisms, addition being potent antioxidant anti-inflammatory agent. Cu...

Bisphenol A (BPA) is used in the manufacture of polycarbonate plastics and epoxy resins; therefore, exposure to BPA is increasing every day. BPA has toxic effects on various human tissues. Curcumin, a yellow polyphenol, is the active turmeric ingredient. It is an efficacious and safe compound with multiple pharmacological activities including antioxidant, ant carcinogenic, ant proliferative, an...

BACKGROUND Heat causes bronchial epithelial cell apoptosis, which is a known factor contributing to airway damage during inhalation injury. Accumulating evidence has shown the effect of curcumin on inhibiting apoptosis. In this study, we investigated whether curcumin suppresses heat-induced apoptosis in bronchial epithelial cells and the underlying mechanism. METHODS Bronchial epithelial cell...

The purpose of this study was investigating the effects of curcumin on the histological changes and functional recovery following spinal cord injury (SCI) in a rat model. Following either sham operation or SCI, 36 male Sprague-Dawley rats were distributed into three groups: sham group, curcumin-treated group, and vehicle-injected group. Locomotor function was assessed according to the Basso, Be...