Tonic conductance mediated by extrasynaptic GABAA receptors has been implicated in the modulation of network oscillatory activity. Using an in vitro brain slice to produce oscillatory activity and a kinetic model of GABAA receptor dynamics, we show that changes in tonic inhibitory input to fast spiking interneurons underlie benzodiazepine-site mediated modulation of neuronal network synchrony i...

this paper describes 3d-qsar analysis and biological evaluation of 1,5-benzodiazepine analogues. benzodiazepine nucleus with its simple structure gives a good opportunity for further modification regarding an increase of its antimicrobial activity. we synthesized a series of benzodiazepine analogues from condensation of various chalcones and halo substituted o-phenelynene diamines. all compound...

The 18 kDa translocator protein (TSPO) is an evolutionarily conserved transmembrane found embedded in the outer mitochondrial membrane. A secondary target for benzodiazepine diazepam, TSPO has been a of interest researchers decades, particularly owing to its well-established links inflammatory conditions central and peripheral nervous systems. It become key biomarker assessing microglial activa...

Two types of benzodiazepine receptors have been demonstrated in mammalian tissues, one which is localized on neuronal elements in brain and the other, on glial cells and in peripheral tissues such as kidney. In vivo administration of 3H-labeled PK 11195 [1-(2-chlorophenyl-N-methyl-N-(1-methylpropyl)-3-isoquinoline carboxamide] or [3H]flunitrazepam with 5 mg of clonazepam per kg to rats with int...

OBJECTIVE To evaluate the possible association between benzodiazepine use and subsequent cancer risk in Taiwan. METHOD In this population-based retrospective cohort study, we used data from 1996 to 2000 from the Taiwanese National Health Insurance system to investigate the possible association between benzodiazepine use and cancer risk. The exposure cohort (mean age = 47.9 years, standard dev...

BACKGROUND Alcohol withdrawal protocols involving symptom-triggered administration of benzodiazepine have been established to reduce the duration of treatment and the cumulative benzodiazepine dose (relative to usual care). However, the effects of a protocol combining fixed-schedule and symptom-triggered benzodiazepine dosing are less clear. OBJECTIVE To assess the efficacy and safety of a co...

OBJECTIVE To compare how newly initiated treatment with benzodiazepines, Z-hypnotics or both associates with the reception of disability pension among 40,661 individuals of a working age. DESIGN Prescription register study. SETTING Norwegian nationwide prescriptions socio-economic and disability status data. METHODS Cox regression analyses. SUBJECTS New benzodiazepine or Z-hypnotic user...

The effects of corticotropin-releasing factor (CRF), a benzodiazepine inverse agonist (methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate; DMCM) and electric foot-shock on rat conflict behavior were characterized and compared. Rats were trained to lever press under a multiple fixed-ratio schedule (FR 20) of food reinforcement in which responses during the first component were not punishe...

a quasi. experimental study was conducted to investigate the antagonistic effect of flumazenil on the   recovery of patients above the age 50 year from anaesthesia receiving benzodiazepine products in one of   iran medical sciences university hospital's operating rooms .   a total of sixty middle aged patients were selected sequentially . thirty of them (12 females and 18 males )   were in...

The brain regions that may be functionally involved in the control of anxiety and the development of seizures were examined using quantitative 1-14C-deoxyglucose autoradiography. For this purpose, beta-carbolines FG 7142 and DMCM were employed. They exert their effects via the benzodiazepine receptor, and whereas both possess anxiogenic properties, FG 7142 is a proconvulsant and DMCM a potent c...