Background Interleukin-15 (IL-15) mediates the function of some innate and adaptive immune cells, which makes it an attractive target as an anti-cancer agent. Gene electrotransfer (GET) has been used to safely deliver plasmid DNA (pDNA) to tissues in a number of pre-clinical and clinical studies for cancer therapy. Previously we have shown using GET to deliver interleukin-15 (IL-15) to mouse me...

The crystal structure of mercurous iodide, Hg(2)I(2), has been determined previously from X-ray powder diffraction data [Havighurst (1926 ▶). J. Am. Chem. Soc.48, 2113-2125]. The results of the current redetermination based on single-crystal X-ray diffraction data provide more precise geometrical data and also anisotropic displacement parameters for the Hg and I atoms, which are both situated o...

This research used geocoded data from 11 waves (2000-2010) of the German Socio-economic Panel Study to investigate the spatial distances of young adults' initial move-outs (N=2113) from their parents' homes. Linear regression models predicted moving distances by factors at individual, family, household, and community level. Overall, home leavers moved across very small distances with a median v...

Recently, we proposed an autoregressive linear mixed effects model for the analysis of longitudinal data in which the current response is regressed on the previous response, fixed effects, and random effects (Funatogawa et al., Statist. Med. 2007; 26:2113-2130). The model represents profiles approaching random equilibriums. Because intermittent missing is an inherent problem of the autoregressi...

We propose and apply a new test of Einstein's Equivalence Principle (EEP) based on the gravitational redshift induced by central super massive black hole quasars in surrounding accretion disk. Specifically, we compare observed Fe III$\lambda\lambda$2039-2113 emission line blend with predicted values wide, uncharted, cosmic territory ($0 \lesssim z_{cosm}\lesssim3$). For first time measure, stat...

Several papers in the BJPsych this month present findings that challenge accepted notions in psychiatry, and one paper focuses specifically on the extent to which the findings of highly cited papers are subsequently replicated. Tajika et al (pp. 357–362) identified highly cited studies claiming evidence of effective treatments reported in a range of high-impact general medical and psychiatric j...

Gunnell et al (pp. 298–305) investigate whether the established association between impaired intellectual performance and schizophrenia is due to the confounding influence of adverse prenatal and early childhood exposures on both intellectual development and the risk of schizophrenia. By studying a large cohort of Swedish male conscripts, results show that the association is not explained by ce...

In the title molecular salt, C(10)H(15)NH(3) (+)·C(7)H(5)O(2) (-), both carboxyl O atoms act as acceptors for strong N-H⋯O inter-molecular hydrogen-bond inter-actions with the ammonium group in the cation, generating infinite chains along the b axis. A weak C-H⋯π inter-action is also present.

In this communication, we demonstrate our recent finding that iron-substituted SBA-15 (Fe-SBA-15) microparticles possess intrinsic peroxidase-like activity and can catalyze the oxidation of peroxidase substrate 3,3',5,5'-tetramethylbenzidine (TMB) by H(2)O(2) to develop a blue color in aqueous solution, leading to a simple approach towards colorimetric detection of H(2)O(2) with a linear detect...