MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression at the post-transcriptional level through base-pairing predominantly with a 3-untranslated region of target mRNA, followed by mRNA degradation or translational repression. Totally, miRNAs change, complex regulatory network, more than 60% human genes. MiRNAs key regulators immune response affect maturation, proli...

I. The blood-brain barrier . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 143 A. Morphology and function. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 143 B. Mechanisms of transport of compounds across the blood-brain barrier . . . . ....

MicroR-146 (miR-146) plays crucial roles in attenuating nerve injury during cerebral ischemia-reperfusion (I/R) injury. The purpose of this study was to investigate the neuroprotective effect miR-146 against I/R Rat model established using 4-vessel occlusion and reperfusion. In study, expression significantly decreased neurons rat compared sham group. addition, miR-146+/+ inflammatory cytokines...

*University Bordeaux 2, Université Bordeaux 1, CNRS, M.A.C. UMR 5227, 146 rue Léo-Saignat, 33076 Bordeaux, France Current address : University Bordeaux 2, ISPED, 146 rue Léo-Saignat, 33076 Bordeaux, France. Current address : University of Miami, Miller School of Medicine, Department of Psychiatry and Behavioral Sciences, 1600 NW 10th Ave. Miami, FL 33136 Current address : Université Bordeaux 2,...

In view of the attractiveness of the basic science involved, and the significance of its applications, it was quite natural and appropriate that a Faraday Discussion in 2010 would be devoted to the Wetting Dynamics of Hydrophobic and Structured Surfaces. Powerful motivation for continued scientific and engineering advances in this area arise from sources as diverse as the fundamental role of hy...

The Australian Senate has completed an inquiry into aircraft air quality in the BAe 146 aircraft because of many incidents of apparent toxic illness among the crew. The Senate Committee concluded that cabin contamination continues to occur(1) and that this has led to short-term and medium-term health problems for a number of BAe 146 flight crew.(1) The inquiry has tested the ability of medical ...