Oestrus ovis is an economically important parasite of small ruminants and a zoonotic parasite with many reports of ophthalmomyiasis in human from Iran and other countries. The aim of the peresent studywas the isolation and identification of excretory-secretory (ES) and somatic (S) antigens of O. ovis second and third stage larvae (L2, L3) collected from Arabi sheep breeds loca...

objective(s):brucellosis is a well-known domestic animal infectious disease, which is caused by brucella bacterium. groel antigen increases brucella survival and is one of the major antigens that stimulates the immune system. hence, the objective of the present study was cloning and bioinformatics analysis of groel gene. materials and methods: the full-length open reading frame of this gene was...

Snakebite is a common problem especially in tropical areas all over the world includingIran. Echis carinatus as one of the most dangerous Iranian snakes is spreading in this countryexcluding central and northwest provinces. In this study gelatinase and fibrinogenolyticproperties as two disintegrating matrix metalloproteinase enzymes were evaluated by a strongclear halo between 56-72 kDa in addi...

MicroRNA are small, non-coding, single-stranded RNAs that are estimated to regulate ~60% of the human genome. MiRNA profiling of monocyte-to-osteoclast differentiation identified miR-142-3p as a miRNA that is significantly, differentially expressed throughout osteoclastogenesis. Enforced expression of miR-142-3p via transient transfection with miR-142-3p mimic inhibited cell-to-cell contact and...

OBJECTIVE The aim of current study was to assess the association between miR-142-3p expression and the prognosis of patients with cervical cancer. PATIENTS AND METHODS Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to assess the expression level of miR-142-3p in cervical cancer tissues and matched normal tissues. Then, statistical analysis was performed to determine ...

Wnt/β-catenin signaling pathway plays essential roles in mammalian development and tissue homeostasis. MicroRNAs (miRNAs) are a class of regulators involved in modulating this pathway. In this study, we screened miRNAs regulating Wnt/β-catenin signaling by using a TopFlash based luciferase reporter. Surprisingly, we found that miR-142 inhibited Wnt/β-catenin signaling, which was inconsistent wi...

MicroRNAs (miRNAs/miRs) serve an important role in the regulation of carcinogenic pathways. RCC is the most prevalent kidney cancer that occurs in adults. miRNAs have gained increasing attention due to their association with RCC tumorigenesis, serving as biomarkers for early detection and progression monitoring, and as potential targets for molecular therapy. Upregulation of miRNA-142-3p has be...

Hematopoietic-specific miR-142 is a critical regulator of various blood cell lineages including CD4 dendritic cells and platelet biogenesis in megakaryocytes. Furthermore, we recently reported that miR-142 is required in order to maintain the biconcave shape of erythrocytes, their structural resilience and lifespan, through a mechanism that involves actin filament homeostasis. Here, we used a m...

The present study was carryout to review the antigens of three (3) medically important Schistosomes namely: Schistosoma mansoni, S. haematobium, and japonicum. parasites-host relationship, antigens, species that produce functions were discussed. Identified include: Sm-24 kDa, Sm108 Polymorphic mucins, 28/30 kDa Protease, 47 protease, 60 Cercarial Elastase (CE) also called Cathepsin, 22.6 23 16 ...